Mutations in the Parkinson’s Disease-Associated PARK2 Gene Are Accompanied by Imbalance in Programmed Cell Death Systems

Parkinson’s disease is caused by the degeneration of midbrain dopaminergic neurons. A rare recessive form of the disease may be caused by a mutation in the PARK2 gene, whose product, Parkin, controls mitophagy and programmed cell death. The level of pro- and anti-apoptotic factors of the Bcl-2 famil...

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Detalles Bibliográficos
Autores principales: Konovalova, E. V., Lopacheva, O. M., Grivennikov, I. A., Lebedeva, O. S., Dashinimaev, E. B., Khaspekov, L. G., Fedotova, E. Yu., Illarioshkin, S. N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717261/
https://www.ncbi.nlm.nih.gov/pubmed/26798503

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