Blockade of senescence‐associated microRNA‐195 in aged skeletal muscle cells facilitates reprogramming to produce induced pluripotent stem cells.

The low reprogramming efficiency in cells from elderly patients is a challenge that must be overcome. Recently, it has been reported that senescence‐associated microRNA (miR)‐195 targets Sirtuin 1 (SIRT1) to advance cellular senescence. Thus, we hypothesized that a blockade of miR‐195 expression cou...

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Detalles Bibliográficos
Autores principales: Kondo, Hideyuki, Kim, Ha Won, Wang, Lei, Okada, Motoi, Paul, Christian, Millard, Ronald W., Wang, Yigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717278/
https://www.ncbi.nlm.nih.gov/pubmed/26637971
http://dx.doi.org/10.1111/acel.12411

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