Protection against acetaminophen-induced acute liver failure by omentum adipose tissue derived stem cells through the mediation of Nrf2 and cytochrome P450 expression

BACKGROUND: Acetaminophen (APAP) overdose causes acute liver failure (ALF) in animals and humans via the rapid depletion of intracellular glutathione (GSH) and the generation of excess reactive oxygen species (ROS) that damage hepatocytes. Stem cell therapy is a potential treatment strategy for ALF....

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Detalles Bibliográficos
Autores principales: Huang, Yu-Jen, Chen, Poda, Lee, Chih-Yuan, Yang, Sin-Yu, Lin, Ming-Tsan, Lee, Hsuan-Shu, Wu, Yao-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717531/
https://www.ncbi.nlm.nih.gov/pubmed/26787241
http://dx.doi.org/10.1186/s12929-016-0231-x

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