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Biologic subtype is a more important prognostic factor than nodal involvement in patients with stages I and II breast carcinoma

PURPOSE: Nodal infiltration has been one of the most important prognostic factors in breast cancer. In recent decades, risk stratification has greatly changed, and is applied in accordance with hormone receptor and human epidermal growth factor receptor 2 (HER2) status. We compared the prognostic po...

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Autores principales: Kim, Hyosun, Cho, Jihyoung, Kwon, Sun Young, Kang, Sun Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Surgical Society 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717602/
https://www.ncbi.nlm.nih.gov/pubmed/26793686
http://dx.doi.org/10.4174/astr.2016.90.1.1
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author Kim, Hyosun
Cho, Jihyoung
Kwon, Sun Young
Kang, Sun Hee
author_facet Kim, Hyosun
Cho, Jihyoung
Kwon, Sun Young
Kang, Sun Hee
author_sort Kim, Hyosun
collection PubMed
description PURPOSE: Nodal infiltration has been one of the most important prognostic factors in breast cancer. In recent decades, risk stratification has greatly changed, and is applied in accordance with hormone receptor and human epidermal growth factor receptor 2 (HER2) status. We compared the prognostic power of tumor subtype to nodal involvement in early breast cancer. METHODS: We reviewed the medical records of 505 patients who had curative surgery for stage I or II breast cancer. We analyzed clinicopathologic factors according to tumor subtype and nodal involvement. Tumors were classified into 4 subtypes according to immunohistochemical status of estrogen receptor, progesterone receptor, HER2, and Ki67 labeling index. Disease-free survival (DFS) and overall survival were analyzed. RESULTS: There were 363 node-negative patients (71.9%) and 142 node-positive patients (28.1%). Luminal A, Luminal B, HER2, and triple-negative breast cancer subtypes were composed of 207 (41.0%), 147 (29.1%), 42 (8.3%), and 109 patients (21.6%), respectively. The median follow-up period was 89.5 months. Node negative-luminal A subtype showed the best prognosis with regard to 5-year DFS, and the pN1-triple negative subtype was associated with the shortest DFS (95.1% vs. 67.8%; hazard ratio, 9.554; P < 0.001). However, the node negative-triple negative subtype was associated with a worse 5-year DFS than the pN1-luminal A subtype ([86.4%; hazard ratio, 2.647; P = 0.048] vs. [93.2%; hazard ratio, 2.061; P = 0.194]). CONCLUSION: Node negative-triple negative breast cancer was associated with a poorer prognosis than pN1-luminal A subtype. Tumor subtype has greater prognostic power compared to nodal status in early breast cancer.
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spelling pubmed-47176022016-01-20 Biologic subtype is a more important prognostic factor than nodal involvement in patients with stages I and II breast carcinoma Kim, Hyosun Cho, Jihyoung Kwon, Sun Young Kang, Sun Hee Ann Surg Treat Res Original Article PURPOSE: Nodal infiltration has been one of the most important prognostic factors in breast cancer. In recent decades, risk stratification has greatly changed, and is applied in accordance with hormone receptor and human epidermal growth factor receptor 2 (HER2) status. We compared the prognostic power of tumor subtype to nodal involvement in early breast cancer. METHODS: We reviewed the medical records of 505 patients who had curative surgery for stage I or II breast cancer. We analyzed clinicopathologic factors according to tumor subtype and nodal involvement. Tumors were classified into 4 subtypes according to immunohistochemical status of estrogen receptor, progesterone receptor, HER2, and Ki67 labeling index. Disease-free survival (DFS) and overall survival were analyzed. RESULTS: There were 363 node-negative patients (71.9%) and 142 node-positive patients (28.1%). Luminal A, Luminal B, HER2, and triple-negative breast cancer subtypes were composed of 207 (41.0%), 147 (29.1%), 42 (8.3%), and 109 patients (21.6%), respectively. The median follow-up period was 89.5 months. Node negative-luminal A subtype showed the best prognosis with regard to 5-year DFS, and the pN1-triple negative subtype was associated with the shortest DFS (95.1% vs. 67.8%; hazard ratio, 9.554; P < 0.001). However, the node negative-triple negative subtype was associated with a worse 5-year DFS than the pN1-luminal A subtype ([86.4%; hazard ratio, 2.647; P = 0.048] vs. [93.2%; hazard ratio, 2.061; P = 0.194]). CONCLUSION: Node negative-triple negative breast cancer was associated with a poorer prognosis than pN1-luminal A subtype. Tumor subtype has greater prognostic power compared to nodal status in early breast cancer. The Korean Surgical Society 2016-01 2015-12-29 /pmc/articles/PMC4717602/ /pubmed/26793686 http://dx.doi.org/10.4174/astr.2016.90.1.1 Text en Copyright © 2016, the Korean Surgical Society http://creativecommons.org/licenses/by-nc/4.0/ Annals of Surgical Treatment and Research is an Open Access Journal. All articles are distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Hyosun
Cho, Jihyoung
Kwon, Sun Young
Kang, Sun Hee
Biologic subtype is a more important prognostic factor than nodal involvement in patients with stages I and II breast carcinoma
title Biologic subtype is a more important prognostic factor than nodal involvement in patients with stages I and II breast carcinoma
title_full Biologic subtype is a more important prognostic factor than nodal involvement in patients with stages I and II breast carcinoma
title_fullStr Biologic subtype is a more important prognostic factor than nodal involvement in patients with stages I and II breast carcinoma
title_full_unstemmed Biologic subtype is a more important prognostic factor than nodal involvement in patients with stages I and II breast carcinoma
title_short Biologic subtype is a more important prognostic factor than nodal involvement in patients with stages I and II breast carcinoma
title_sort biologic subtype is a more important prognostic factor than nodal involvement in patients with stages i and ii breast carcinoma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717602/
https://www.ncbi.nlm.nih.gov/pubmed/26793686
http://dx.doi.org/10.4174/astr.2016.90.1.1
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