Resistance to BRAF inhibitors induces glutamine dependency in melanoma cells

BRAF inhibitors can extend progression‐free and overall survival in melanoma patients whose tumors harbor mutations in BRAF. However, the majority of patients eventually develop resistance to these drugs. Here we show that BRAF mutant melanoma cells that have developed acquired resistance to BRAF in...

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Detalles Bibliográficos
Autores principales: Baenke, Franziska, Chaneton, Barbara, Smith, Matthew, Van Den Broek, Niels, Hogan, Kate, Tang, Haoran, Viros, Amaya, Martin, Matthew, Galbraith, Laura, Girotti, Maria R., Dhomen, Nathalie, Gottlieb, Eyal, Marais, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717845/
https://www.ncbi.nlm.nih.gov/pubmed/26365896
http://dx.doi.org/10.1016/j.molonc.2015.08.003

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