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Follow-up of N400 in the Rehabilitation of First-episode Schizophrenia
BACKGROUND: The N400 component of event-related potentials (ERP) has recently drawn widespread attention at home and abroad. This study was to explore the relationship between N400 changes and risperidone treatment and rehabilitation in first-episode schizophrenia (FES). METHODS: ERP component N400...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717989/ https://www.ncbi.nlm.nih.gov/pubmed/26265616 http://dx.doi.org/10.4103/0366-6999.162499 |
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author | Du, Xiang-Dong Zhang, Guang-Ya Yang, Yong Li, Zhe Pan, Wen Yin, Guang-Zhong Dong, Ri-Xia Gai, Hai-Jun Ye, Gang Yang, Jian-Gong Yuan, Ying Pan, Neng-Rong Li, Wei-Qin Xu, Xiao-Wen Chen, Xing-Shi |
author_facet | Du, Xiang-Dong Zhang, Guang-Ya Yang, Yong Li, Zhe Pan, Wen Yin, Guang-Zhong Dong, Ri-Xia Gai, Hai-Jun Ye, Gang Yang, Jian-Gong Yuan, Ying Pan, Neng-Rong Li, Wei-Qin Xu, Xiao-Wen Chen, Xing-Shi |
author_sort | Du, Xiang-Dong |
collection | PubMed |
description | BACKGROUND: The N400 component of event-related potentials (ERP) has recently drawn widespread attention at home and abroad. This study was to explore the relationship between N400 changes and risperidone treatment and rehabilitation in first-episode schizophrenia (FES). METHODS: ERP component N400 was recorded by Guangzhou Runjie WJ-1 ERP instruments, in 58 FES before and 6 months, 15 months after risperidone treatment, and in 62 normal controls. The patients’ syndromes were assessed by Positive and Negative Syndrome Scale (PANSS). And the stimuli are Chinese sentences with matching (congruent) or mismatching (incongruent) ending words. RESULTS: N400 latencies were prolonged, and amplitudes were decreased in Cz, Pz, Fz, C3, C4, in FES compared with in NC, before treatment. The prolonged N400 latencies and decreased amplitudes were negatively correlated with the patients’ positive scale and total scale of PANSS. There are significant differences of N400 amplitudes and latencies in 6 months and 15 months follow-up after treatment. Before treatment, 6 months and 15 months after treatment, N400 latencies are 446 ± 35 ms, 440 ± 37 ms, 414 ± 31 ms (F = 9.72, P < 0.01) in incongruent situation; N400 amplitudes are 5.2 ± 4.6 μV, 5.7 ± 4.8 μV, 7.3 ± 5.0 μV (F = 2.06, P > 0.05) in congruent situation, and 8.5 ± 5.9 μV, 10.1 ± 5.0 μV, 11.9 ± 7.0 μV (F = 3.697, P < 0.05) in incongruent situation. CONCLUSIONS: N400 could be used to predict the effects of treatment of schizophrenia to some degree. The linguistic and cognitive impairment in schizophrenia can be improved by antipsychotic drugs. |
format | Online Article Text |
id | pubmed-4717989 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-47179892016-04-04 Follow-up of N400 in the Rehabilitation of First-episode Schizophrenia Du, Xiang-Dong Zhang, Guang-Ya Yang, Yong Li, Zhe Pan, Wen Yin, Guang-Zhong Dong, Ri-Xia Gai, Hai-Jun Ye, Gang Yang, Jian-Gong Yuan, Ying Pan, Neng-Rong Li, Wei-Qin Xu, Xiao-Wen Chen, Xing-Shi Chin Med J (Engl) Original Article BACKGROUND: The N400 component of event-related potentials (ERP) has recently drawn widespread attention at home and abroad. This study was to explore the relationship between N400 changes and risperidone treatment and rehabilitation in first-episode schizophrenia (FES). METHODS: ERP component N400 was recorded by Guangzhou Runjie WJ-1 ERP instruments, in 58 FES before and 6 months, 15 months after risperidone treatment, and in 62 normal controls. The patients’ syndromes were assessed by Positive and Negative Syndrome Scale (PANSS). And the stimuli are Chinese sentences with matching (congruent) or mismatching (incongruent) ending words. RESULTS: N400 latencies were prolonged, and amplitudes were decreased in Cz, Pz, Fz, C3, C4, in FES compared with in NC, before treatment. The prolonged N400 latencies and decreased amplitudes were negatively correlated with the patients’ positive scale and total scale of PANSS. There are significant differences of N400 amplitudes and latencies in 6 months and 15 months follow-up after treatment. Before treatment, 6 months and 15 months after treatment, N400 latencies are 446 ± 35 ms, 440 ± 37 ms, 414 ± 31 ms (F = 9.72, P < 0.01) in incongruent situation; N400 amplitudes are 5.2 ± 4.6 μV, 5.7 ± 4.8 μV, 7.3 ± 5.0 μV (F = 2.06, P > 0.05) in congruent situation, and 8.5 ± 5.9 μV, 10.1 ± 5.0 μV, 11.9 ± 7.0 μV (F = 3.697, P < 0.05) in incongruent situation. CONCLUSIONS: N400 could be used to predict the effects of treatment of schizophrenia to some degree. The linguistic and cognitive impairment in schizophrenia can be improved by antipsychotic drugs. Medknow Publications & Media Pvt Ltd 2015-08-20 /pmc/articles/PMC4717989/ /pubmed/26265616 http://dx.doi.org/10.4103/0366-6999.162499 Text en Copyright: © 2015 Chinese Medical Journal http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Du, Xiang-Dong Zhang, Guang-Ya Yang, Yong Li, Zhe Pan, Wen Yin, Guang-Zhong Dong, Ri-Xia Gai, Hai-Jun Ye, Gang Yang, Jian-Gong Yuan, Ying Pan, Neng-Rong Li, Wei-Qin Xu, Xiao-Wen Chen, Xing-Shi Follow-up of N400 in the Rehabilitation of First-episode Schizophrenia |
title | Follow-up of N400 in the Rehabilitation of First-episode Schizophrenia |
title_full | Follow-up of N400 in the Rehabilitation of First-episode Schizophrenia |
title_fullStr | Follow-up of N400 in the Rehabilitation of First-episode Schizophrenia |
title_full_unstemmed | Follow-up of N400 in the Rehabilitation of First-episode Schizophrenia |
title_short | Follow-up of N400 in the Rehabilitation of First-episode Schizophrenia |
title_sort | follow-up of n400 in the rehabilitation of first-episode schizophrenia |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717989/ https://www.ncbi.nlm.nih.gov/pubmed/26265616 http://dx.doi.org/10.4103/0366-6999.162499 |
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