The CII-specific autoimmune T-cell response develops in the presence of FTY720 but is regulated by enhanced Treg cells that inhibit the development of autoimmune arthritis

BACKGROUND: Fingolimod (FTY720) is an immunomodulating drug that inhibits sphingosine-1-phosphate binding and blocks T-cell egress from lymph nodes. We analyzed the effect of FTY720 on the autoimmune T- and B-cell response in autoimmune arthritis and studied the mechanisms by which it alters the fun...

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Detalles Bibliográficos
Autores principales: Miller, David C., Whittington, Karen B., Brand, David D., Hasty, Karen A., Rosloniec, Edward F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718028/
https://www.ncbi.nlm.nih.gov/pubmed/26757712
http://dx.doi.org/10.1186/s13075-015-0909-6

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