In vitro eradication of citrullinated protein specific B-lymphocytes of rheumatoid arthritis patients by targeted bifunctional nanoparticles

BACKGROUND: Autoreactive B cells are crucial players in the pathogenesis of rheumatoid arthritis (RA). Autoantibodies specific for citrullinated proteins (ACPA), present in the serum of approximately 60–70 % of patients, have a pathogenic role in the disease. B cell depleting therapies may result in...

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Detalles Bibliográficos
Autores principales: Pozsgay, Judit, Babos, Fruzsina, Uray, Katalin, Magyar, Anna, Gyulai, Gergő, Kiss, Éva, Nagy, György, Rojkovich, Bernadette, Hudecz, Ferenc, Sármay, Gabriella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718042/
https://www.ncbi.nlm.nih.gov/pubmed/26780830
http://dx.doi.org/10.1186/s13075-016-0918-0

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