A novel role for the cell cycle regulatory complex cyclin D1–CDK4 in gluconeogenesis

Dysregulation of gluconeogenesis is a key pathological feature of type 2 diabetes. However, the molecular mechanisms underlying the regulation of gluconeogenesis remain unclear. Bhalla et al. recently reported that cyclin D1 suppresses hepatic gluconeogenesis through CDK4‐dependent phosphorylation of PGC1alpha and consequent inhibition of its activity. The cyclin D1–CDK4 might thus serve as an important link between the cell cycle and control of energy metabolism through modulation of PGC1alpha activity. [Image: see text]