A novel role for the cell cycle regulatory complex cyclin D1–CDK4 in gluconeogenesis

Dysregulation of gluconeogenesis is a key pathological feature of type 2 diabetes. However, the molecular mechanisms underlying the regulation of gluconeogenesis remain unclear. Bhalla et al. recently reported that cyclin D1 suppresses hepatic gluconeogenesis through CDK4‐dependent phosphorylation o...

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Detalles Bibliográficos
Autores principales: Hosooka, Tetsuya, Ogawa, Wataru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718093/
https://www.ncbi.nlm.nih.gov/pubmed/26816597
http://dx.doi.org/10.1111/jdi.12369
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author Hosooka, Tetsuya
Ogawa, Wataru
author_facet Hosooka, Tetsuya
Ogawa, Wataru
author_sort Hosooka, Tetsuya
collection PubMed
description Dysregulation of gluconeogenesis is a key pathological feature of type 2 diabetes. However, the molecular mechanisms underlying the regulation of gluconeogenesis remain unclear. Bhalla et al. recently reported that cyclin D1 suppresses hepatic gluconeogenesis through CDK4‐dependent phosphorylation of PGC1alpha and consequent inhibition of its activity. The cyclin D1–CDK4 might thus serve as an important link between the cell cycle and control of energy metabolism through modulation of PGC1alpha activity. [Image: see text]
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spelling pubmed-47180932016-01-26 A novel role for the cell cycle regulatory complex cyclin D1–CDK4 in gluconeogenesis Hosooka, Tetsuya Ogawa, Wataru J Diabetes Investig Commentaries Dysregulation of gluconeogenesis is a key pathological feature of type 2 diabetes. However, the molecular mechanisms underlying the regulation of gluconeogenesis remain unclear. Bhalla et al. recently reported that cyclin D1 suppresses hepatic gluconeogenesis through CDK4‐dependent phosphorylation of PGC1alpha and consequent inhibition of its activity. The cyclin D1–CDK4 might thus serve as an important link between the cell cycle and control of energy metabolism through modulation of PGC1alpha activity. [Image: see text] John Wiley and Sons Inc. 2015-06-08 2016-01 /pmc/articles/PMC4718093/ /pubmed/26816597 http://dx.doi.org/10.1111/jdi.12369 Text en © 2015 The Authors. Journal of Diabetes Investigation published by Asian Association of the Study of Diabetes (AASD) and Wiley Publishing Asia Pty Ltd This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Commentaries
Hosooka, Tetsuya
Ogawa, Wataru
A novel role for the cell cycle regulatory complex cyclin D1–CDK4 in gluconeogenesis
title A novel role for the cell cycle regulatory complex cyclin D1–CDK4 in gluconeogenesis
title_full A novel role for the cell cycle regulatory complex cyclin D1–CDK4 in gluconeogenesis
title_fullStr A novel role for the cell cycle regulatory complex cyclin D1–CDK4 in gluconeogenesis
title_full_unstemmed A novel role for the cell cycle regulatory complex cyclin D1–CDK4 in gluconeogenesis
title_short A novel role for the cell cycle regulatory complex cyclin D1–CDK4 in gluconeogenesis
title_sort novel role for the cell cycle regulatory complex cyclin d1–cdk4 in gluconeogenesis
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718093/
https://www.ncbi.nlm.nih.gov/pubmed/26816597
http://dx.doi.org/10.1111/jdi.12369
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