A novel protocol for the one-pot borylation/Suzuki reaction provides easy access to hinge-binding groups for kinase inhibitors

The one-pot borylation/Suzuki reaction is a very efficient means of accessing cross-coupling products of two aryl-halide partners that generally requires the use of specific catalysts or ligands and/or relatively long reaction times. This new microwave-assisted method provides a quick one-pot boryla...

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Detalles Bibliográficos
Autores principales: Hooper, A., Zambon, A., Springer, C. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718143/
https://www.ncbi.nlm.nih.gov/pubmed/26620576
http://dx.doi.org/10.1039/c5ob01915j
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author Hooper, A.
Zambon, A.
Springer, C. J.
author_facet Hooper, A.
Zambon, A.
Springer, C. J.
author_sort Hooper, A.
collection PubMed
description The one-pot borylation/Suzuki reaction is a very efficient means of accessing cross-coupling products of two aryl-halide partners that generally requires the use of specific catalysts or ligands and/or relatively long reaction times. This new microwave-assisted method provides a quick one-pot borylation/Suzuki reaction protocol that we applied to the synthesis of various bi- or poly-aryl scaffolds, including a variety of aryl and heteroaryl ring systems and the core frameworks of kinase inhibitors vemurafenib and GDC-0879.
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spelling pubmed-47181432016-02-03 A novel protocol for the one-pot borylation/Suzuki reaction provides easy access to hinge-binding groups for kinase inhibitors Hooper, A. Zambon, A. Springer, C. J. Org Biomol Chem Chemistry The one-pot borylation/Suzuki reaction is a very efficient means of accessing cross-coupling products of two aryl-halide partners that generally requires the use of specific catalysts or ligands and/or relatively long reaction times. This new microwave-assisted method provides a quick one-pot borylation/Suzuki reaction protocol that we applied to the synthesis of various bi- or poly-aryl scaffolds, including a variety of aryl and heteroaryl ring systems and the core frameworks of kinase inhibitors vemurafenib and GDC-0879. Royal Society of Chemistry 2016-01-21 2015-12-01 /pmc/articles/PMC4718143/ /pubmed/26620576 http://dx.doi.org/10.1039/c5ob01915j Text en This journal is © The Royal Society of Chemistry 2015 http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Hooper, A.
Zambon, A.
Springer, C. J.
A novel protocol for the one-pot borylation/Suzuki reaction provides easy access to hinge-binding groups for kinase inhibitors
title A novel protocol for the one-pot borylation/Suzuki reaction provides easy access to hinge-binding groups for kinase inhibitors
title_full A novel protocol for the one-pot borylation/Suzuki reaction provides easy access to hinge-binding groups for kinase inhibitors
title_fullStr A novel protocol for the one-pot borylation/Suzuki reaction provides easy access to hinge-binding groups for kinase inhibitors
title_full_unstemmed A novel protocol for the one-pot borylation/Suzuki reaction provides easy access to hinge-binding groups for kinase inhibitors
title_short A novel protocol for the one-pot borylation/Suzuki reaction provides easy access to hinge-binding groups for kinase inhibitors
title_sort novel protocol for the one-pot borylation/suzuki reaction provides easy access to hinge-binding groups for kinase inhibitors
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718143/
https://www.ncbi.nlm.nih.gov/pubmed/26620576
http://dx.doi.org/10.1039/c5ob01915j
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