Cargando…
How, with whom and when: an overview of CD147-mediated regulatory networks influencing matrix metalloproteinase activity
Matrix metalloproteinases (MMPs) comprise a family of 23 zinc-dependent enzymes involved in various pathologic and physiologic processes. In cancer, MMPs contribute to processes from tumour initiation to establishment of distant metastases. Complex signalling and protein transport networks regulate...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718507/ https://www.ncbi.nlm.nih.gov/pubmed/26604323 http://dx.doi.org/10.1042/BSR20150256 |
_version_ | 1782410807672307712 |
---|---|
author | Grass, G. Daniel Toole, Bryan P. |
author_facet | Grass, G. Daniel Toole, Bryan P. |
author_sort | Grass, G. Daniel |
collection | PubMed |
description | Matrix metalloproteinases (MMPs) comprise a family of 23 zinc-dependent enzymes involved in various pathologic and physiologic processes. In cancer, MMPs contribute to processes from tumour initiation to establishment of distant metastases. Complex signalling and protein transport networks regulate MMP synthesis, cell surface presentation and release. Earlier attempts to disrupt MMP activity in patients have proven to be intolerable and with underwhelming clinical efficacy; thus targeting ancillary proteins that regulate MMP activity may be a useful therapeutic approach. Extracellular matrix metalloproteinase inducer (EMMPRIN) was originally characterized as a factor present on lung cancer cells, which stimulated collagenase (MMP-1) production in fibroblasts. Subsequent studies demonstrated that EMMPRIN was identical with several other protein factors, including basigin (Bsg), all of which are now commonly termed CD147. CD147 modulates the synthesis and activity of soluble and membrane-bound [membrane-type MMPs (MT-MMPs)] in various contexts via homophilic/heterophilic cell interactions, vesicular shedding or cell-autonomous processes. CD147 also participates in inflammation, nutrient and drug transporter activity, microbial pathology and developmental processes. Despite the hundreds of manuscripts demonstrating CD147-mediated MMP regulation, the molecular underpinnings governing this process have not been fully elucidated. The present review summarizes our present knowledge of the complex regulatory systems influencing CD147 biology and provides a framework to understand how CD147 may influence MMP activity. |
format | Online Article Text |
id | pubmed-4718507 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-47185072016-02-02 How, with whom and when: an overview of CD147-mediated regulatory networks influencing matrix metalloproteinase activity Grass, G. Daniel Toole, Bryan P. Biosci Rep Review Articles Matrix metalloproteinases (MMPs) comprise a family of 23 zinc-dependent enzymes involved in various pathologic and physiologic processes. In cancer, MMPs contribute to processes from tumour initiation to establishment of distant metastases. Complex signalling and protein transport networks regulate MMP synthesis, cell surface presentation and release. Earlier attempts to disrupt MMP activity in patients have proven to be intolerable and with underwhelming clinical efficacy; thus targeting ancillary proteins that regulate MMP activity may be a useful therapeutic approach. Extracellular matrix metalloproteinase inducer (EMMPRIN) was originally characterized as a factor present on lung cancer cells, which stimulated collagenase (MMP-1) production in fibroblasts. Subsequent studies demonstrated that EMMPRIN was identical with several other protein factors, including basigin (Bsg), all of which are now commonly termed CD147. CD147 modulates the synthesis and activity of soluble and membrane-bound [membrane-type MMPs (MT-MMPs)] in various contexts via homophilic/heterophilic cell interactions, vesicular shedding or cell-autonomous processes. CD147 also participates in inflammation, nutrient and drug transporter activity, microbial pathology and developmental processes. Despite the hundreds of manuscripts demonstrating CD147-mediated MMP regulation, the molecular underpinnings governing this process have not been fully elucidated. The present review summarizes our present knowledge of the complex regulatory systems influencing CD147 biology and provides a framework to understand how CD147 may influence MMP activity. Portland Press Ltd. 2016-01-15 /pmc/articles/PMC4718507/ /pubmed/26604323 http://dx.doi.org/10.1042/BSR20150256 Text en © 2016 Authors http://creativecommons.org/licenses/by/3.0/ This is an open access article published by Portland Press Limited and distributed under the Creative Commons Attribution Licence 3.0 (http://creativecommons.org/licenses/by/3.0/) . |
spellingShingle | Review Articles Grass, G. Daniel Toole, Bryan P. How, with whom and when: an overview of CD147-mediated regulatory networks influencing matrix metalloproteinase activity |
title | How, with whom and when: an overview of CD147-mediated regulatory networks influencing matrix metalloproteinase activity |
title_full | How, with whom and when: an overview of CD147-mediated regulatory networks influencing matrix metalloproteinase activity |
title_fullStr | How, with whom and when: an overview of CD147-mediated regulatory networks influencing matrix metalloproteinase activity |
title_full_unstemmed | How, with whom and when: an overview of CD147-mediated regulatory networks influencing matrix metalloproteinase activity |
title_short | How, with whom and when: an overview of CD147-mediated regulatory networks influencing matrix metalloproteinase activity |
title_sort | how, with whom and when: an overview of cd147-mediated regulatory networks influencing matrix metalloproteinase activity |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718507/ https://www.ncbi.nlm.nih.gov/pubmed/26604323 http://dx.doi.org/10.1042/BSR20150256 |
work_keys_str_mv | AT grassgdaniel howwithwhomandwhenanoverviewofcd147mediatedregulatorynetworksinfluencingmatrixmetalloproteinaseactivity AT toolebryanp howwithwhomandwhenanoverviewofcd147mediatedregulatorynetworksinfluencingmatrixmetalloproteinaseactivity |