Diverse Molecular Targets for Chalcones with Varied Bioactivities

Natural or synthetic chalcones with different substituents have revealed a variety of biological activities that may benefit human health. The underlying mechanisms of action, particularly with respect to the direct cellular targets and the modes of interaction with the targets, have not been rigoro...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Bo, Xing, Chengguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718574/
https://www.ncbi.nlm.nih.gov/pubmed/26798565
http://dx.doi.org/10.4172/2161-0444.1000291
_version_ 1782410818902556672
author Zhou, Bo
Xing, Chengguo
author_facet Zhou, Bo
Xing, Chengguo
author_sort Zhou, Bo
collection PubMed
description Natural or synthetic chalcones with different substituents have revealed a variety of biological activities that may benefit human health. The underlying mechanisms of action, particularly with respect to the direct cellular targets and the modes of interaction with the targets, have not been rigorously characterized, which imposes challenges to structure-guided rational development of therapeutic agents or chemical probes with acceptable target-selectivity profile. This review summarizes literature evidence on chalcones’ direct molecular targets in the context of their biological activities.
format Online
Article
Text
id pubmed-4718574
institution National Center for Biotechnology Information
language English
publishDate 2015
record_format MEDLINE/PubMed
spelling pubmed-47185742016-01-19 Diverse Molecular Targets for Chalcones with Varied Bioactivities Zhou, Bo Xing, Chengguo Med Chem (Los Angeles) Article Natural or synthetic chalcones with different substituents have revealed a variety of biological activities that may benefit human health. The underlying mechanisms of action, particularly with respect to the direct cellular targets and the modes of interaction with the targets, have not been rigorously characterized, which imposes challenges to structure-guided rational development of therapeutic agents or chemical probes with acceptable target-selectivity profile. This review summarizes literature evidence on chalcones’ direct molecular targets in the context of their biological activities. 2015-08-22 2015-08 /pmc/articles/PMC4718574/ /pubmed/26798565 http://dx.doi.org/10.4172/2161-0444.1000291 Text en http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Zhou, Bo
Xing, Chengguo
Diverse Molecular Targets for Chalcones with Varied Bioactivities
title Diverse Molecular Targets for Chalcones with Varied Bioactivities
title_full Diverse Molecular Targets for Chalcones with Varied Bioactivities
title_fullStr Diverse Molecular Targets for Chalcones with Varied Bioactivities
title_full_unstemmed Diverse Molecular Targets for Chalcones with Varied Bioactivities
title_short Diverse Molecular Targets for Chalcones with Varied Bioactivities
title_sort diverse molecular targets for chalcones with varied bioactivities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718574/
https://www.ncbi.nlm.nih.gov/pubmed/26798565
http://dx.doi.org/10.4172/2161-0444.1000291
work_keys_str_mv AT zhoubo diversemoleculartargetsforchalconeswithvariedbioactivities
AT xingchengguo diversemoleculartargetsforchalconeswithvariedbioactivities

Ejemplares similares