Global 5-Hydroxymethylcytosine Levels Are Profoundly Reduced in Multiple Genitourinary Malignancies

Solid tumors are characterized by a plethora of epigenetic changes. In particular, patterns methylation of cytosines at the 5-position (5mC) in the context of CpGs are frequently altered in tumors. Recent evidence suggests that 5mC can get converted to 5-hydroxylmethylcytosine (5hmC) in an enzymatic...

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Detalles Bibliográficos
Autores principales: Munari, Enrico, Chaux, Alcides, Vaghasia, Ajay M., Taheri, Diana, Karram, Sarah, Bezerra, Stephania M., Gonzalez Roibon, Nilda, Nelson, William G., Yegnasubramanian, Srinivasan, Netto, George J., Haffner, Michael C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718593/
https://www.ncbi.nlm.nih.gov/pubmed/26785262
http://dx.doi.org/10.1371/journal.pone.0146302

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