Cargando…

Ceramide Synthase 6 Is a Novel Target of Methotrexate Mediating Its Antiproliferative Effect in a p53-Dependent Manner

We previously reported that ceramide synthase 6 (CerS6) is elevated in response to folate stress in cancer cells, leading to enhanced production of C(16)-ceramide and apoptosis. Antifolate methotrexate (MTX), a drug commonly used in chemotherapy of several types of cancer, is a strong inhibitor of f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fekry, Baharan, Esmaeilniakooshkghazi, Amin, Krupenko, Sergey A., Krupenko, Natalia I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718595/ https://www.ncbi.nlm.nih.gov/pubmed/26783755 http://dx.doi.org/10.1371/journal.pone.0146618

Ejemplares similares

C(16)-ceramide is a natural regulatory ligand of p53 in cellular stress response
por: Fekry, Baharan, et al.
Publicado: (2018)

Ceramide Synthase 6: Comparative Analysis, Phylogeny and Evolution
por: Holmes, Roger S., et al.
Publicado: (2018)

Cytosolic 10-formyltetrahydrofolate dehydrogenase regulates glycine metabolism in mouse liver
por: Krupenko, Natalia I., et al.
Publicado: (2019)

CHIP E3 ligase mediates proteasomal degradation of the proliferation regulatory protein ALDH1L1 during the transition of NIH3T3 fibroblasts from G(0)/G(1) to S-phase
por: Khan, Qasim A., et al.
Publicado: (2018)

Dietary Folic Acid Alters Metabolism of Multiple Vitamins in a CerS6- and Sex-Dependent Manner
por: Barron, Keri, et al.
Publicado: (2021)

ALDH1L1 Inhibits Cell Motility Via Dephosphorylation of Cofilin by PP1 and PP2A
por: Oleinik, Natalia V., et al.
Publicado: (2010)

Structure of putative tumor suppressor ALDH1L1
por: Tsybovsky, Yaroslav, et al.
Publicado: (2022)

A Novel Tumor Suppressor Function of Glycine N-Methyltransferase Is Independent of Its Catalytic Activity but Requires Nuclear Localization
por: DebRoy, Suchandra, et al.
Publicado: (2013)

Dietary Methionine Restriction Reverses Liver Cancer Driving Metabotype in GNMT KO Mice
por: Hall, Madeline, et al.
Publicado: (2022)

Is ALDH1L1 Elevated in Lung Cancer? Comment on: Lee, S.-H.; et al. “The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in KRAS-Driven Lung Cancer” Cancers 2020, 12, 1382
por: Krupenko, Sergey A., et al.
Publicado: (2021)

Aldh1l2 knockout mouse metabolomics links the loss of the mitochondrial folate enzyme to deregulation of a lipid metabolism observed in rare human disorder
por: Krupenko, Natalia I., et al.
Publicado: (2020)

The Role of Single-Nucleotide Polymorphisms in the Function of Candidate Tumor Suppressor ALDH1L1
por: Krupenko, Sergey A., et al.
Publicado: (2019)

Knockout of Putative Tumor Suppressor Aldh1l1 in Mice Reprograms Metabolism to Accelerate Growth of Tumors in a Diethylnitrosamine (DEN) Model of Liver Carcinogenesis
por: Krupenko, Natalia I., et al.
Publicado: (2021)

Sex-Specific Metabolic Effects of Dietary Folate Withdrawal in Wild-Type and Aldh1l1 Knockout Mice
por: Sharma, Jaspreet, et al.
Publicado: (2022)

Exploratory Metabolomics Underscores the Folate Enzyme ALDH1L1 as a Regulator of Glycine and Methylation Reactions
por: Rushing, Blake R., et al.
Publicado: (2022)

Deleterious mutations in ALDH1L2 suggest a novel cause for neuro-ichthyotic syndrome
por: Sarret, Catherine, et al.
Publicado: (2019)

JNK1/2 regulate Bid by direct phosphorylation at Thr59 in response to ALDH1L1
por: Prakasam, A, et al.
Publicado: (2014)

Somatic musculature in trematode hermaphroditic generation
por: Krupenko, Darya Y., et al.
Publicado: (2015)

Fatty acid transport protein 2 interacts with ceramide synthase 2 to promote ceramide synthesis
por: Kim, Jiyoon L., et al.
Publicado: (2022)

Ceramide Synthase 6 Maximizes p53 Function to Prevent Progeny Formation from Polyploid Giant Cancer Cells
por: Lu, Ping, et al.
Publicado: (2021)

Horse-Derived Ceramide Accentuates Glucosylceramide Synthase and Ceramide Synthase 3 by Activating PPARβ/δ and/or PPARγ to Stimulate Ceramide Synthesis
por: Igarashi, Tami, et al.
Publicado: (2023)

Silencing of ceramide synthase 2 in hepatocytes modulates plasma ceramide biomarkers predictive of cardiovascular death
por: Schmidt, Steffen, et al.
Publicado: (2022)

Ceramide Synthase 6 Deficiency Enhances Inflammation in the DSS model of Colitis
por: Helke, Kristi, et al.
Publicado: (2018)

Ceramide Synthases Expression and Role of Ceramide Synthase-2 in the Lung: Insight from Human Lung Cells and Mouse Models
por: Petrache, Irina, et al.
Publicado: (2013)

Clocks and Cholesterol: Co-agonists in Cardiovascular Disease?
por: Fekry, Baharan, et al.
Publicado: (2017)

Adoptive Transfer of Ceramide Synthase 6 Deficient Splenocytes Reduces the Development of Colitis
por: Scheffel, Matthew J., et al.
Publicado: (2017)

The Role of Ceramide Synthases in the Pathogenicity of Cryptococcus neoformans
por: Munshi, Mansa A., et al.
Publicado: (2018)

A tissue‐specific screen of ceramide expression in aged mice identifies ceramide synthase‐1 and ceramide synthase‐5 as potential regulators of fiber size and strength in skeletal muscle
por: Tosetti, Bettina, et al.
Publicado: (2019)

Metabolic Phenotype of Wild-Type and As3mt-Knockout C57BL/6J Mice Exposed to Inorganic Arsenic: The Role of Dietary Fat and Folate Intake
por: Huang, Madelyn C., et al.
Publicado: (2018)

Oxidized Phospholipids Induce Ceramide Accumulation in RAW 264.7 Macrophages: Role of Ceramide Synthases
por: Halasiddappa, Lingaraju M., et al.
Publicado: (2013)

Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6
por: Schüll, S, et al.
Publicado: (2015)

Generation of a ceramide synthase 6 mouse lacking the DDRSDIE C-terminal motif
por: Kim, Jiyoon, et al.
Publicado: (2022)

Ceramide Synthase 6 Mediates Triple-Negative Breast Cancer Response to Chemotherapy Through RhoA- and EGFR-Mediated Signaling Pathways
por: Chen, Hui, et al.
Publicado: (2022)

Dependence of ABCB1 transporter expression and function on distinct sphingolipids generated by ceramide synthases-2 and -6 in chemoresistant renal cancer
por: Lee, Wing-Kee, et al.
Publicado: (2021)

Overexpression of ceramide synthase 1 increases C18-ceramide and leads to lethal autophagy in human glioma
por: Wang, Zheng, et al.
Publicado: (2017)

Ceramide compensation by ceramide synthases preserves retinal function and structure in a retinal dystrophy mouse model
por: Qian, Xinye, et al.
Publicado: (2023)

Pancreatic islet protection at the expense of secretory function involves serine-linked mitochondrial one-carbon metabolism
por: Pelligra, Angela, et al.
Publicado: (2023)

Pancreatic islet protection at the expense of secretory function involves serine-linked mitochondrial one-carbon metabolism
por: Pelligra, Angela, et al.
Publicado: (2023)

Functional Loss of Two Ceramide Synthases Elicits Autophagy-Dependent Lifespan Extension in C. elegans
por: Mosbech, Mai-Britt, et al.
Publicado: (2013)

p53 and Ceramide as Collaborators in the Stress Response
por: Hage-Sleiman, Rouba, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_327824kmsvqfj2dj6iu20u7jnu