Dynamic Effects of Topoisomerase I Inhibition on R-Loops and Short Transcripts at Active Promoters

Topoisomerase I-DNA-cleavage complexes (Top1cc) stabilized by camptothecin (CPT) have specific effects at transcriptional levels. We recently reported that Top1cc increase antisense transcript (aRNAs) levels at divergent CpG-island promoters and, transiently, DNA/RNA hybrids (R-loop) in nuclear and...

Descripción completa

Detalles Bibliográficos
Autores principales: Marinello, Jessica, Bertoncini, Stefania, Aloisi, Iris, Cristini, Agnese, Malagoli Tagliazucchi, Guidantonio, Forcato, Mattia, Sordet, Olivier, Capranico, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718701/
https://www.ncbi.nlm.nih.gov/pubmed/26784695
http://dx.doi.org/10.1371/journal.pone.0147053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718701/
https://www.ncbi.nlm.nih.gov/pubmed/26784695
http://dx.doi.org/10.1371/journal.pone.0147053

Ejemplares similares