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Optimal level activity of matrix metalloproteinases is critical for adult visual plasticity in the healthy and stroke-affected brain

The ability of the adult brain to undergo plastic changes is of particular interest in medicine, especially regarding recovery from injuries or improving learning and cognition. Matrix metalloproteinases (MMPs) have been associated with juvenile experience-dependent primary visual cortex (V1) plasti...

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Autores principales: Pielecka-Fortuna, Justyna, Kalogeraki, Evgenia, Fortuna, Michal G, Löwel, Siegrid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718812/
https://www.ncbi.nlm.nih.gov/pubmed/26609811
http://dx.doi.org/10.7554/eLife.11290
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author Pielecka-Fortuna, Justyna
Kalogeraki, Evgenia
Fortuna, Michal G
Löwel, Siegrid
author_facet Pielecka-Fortuna, Justyna
Kalogeraki, Evgenia
Fortuna, Michal G
Löwel, Siegrid
author_sort Pielecka-Fortuna, Justyna
collection PubMed
description The ability of the adult brain to undergo plastic changes is of particular interest in medicine, especially regarding recovery from injuries or improving learning and cognition. Matrix metalloproteinases (MMPs) have been associated with juvenile experience-dependent primary visual cortex (V1) plasticity, yet little is known about their role in this process in the adult V1. Activation of MMPs is a crucial step facilitating structural changes in a healthy brain; however, upon brain injury, upregulated MMPs promote the spread of a lesion and impair recovery. To clarify these seemingly opposing outcomes of MMP-activation, we examined the effects of MMP-inhibition on experience-induced plasticity in healthy and stoke-affected adult mice. In healthy animals, 7-day application of MMP-inhibitor prevented visual plasticity. Additionally, treatment with MMP-inhibitor once but not twice following stroke rescued plasticity, normally lost under these conditions. Our data imply that an optimal level of MMP-activity is crucial for adult visual plasticity to occur. DOI: http://dx.doi.org/10.7554/eLife.11290.001
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spelling pubmed-47188122016-03-17 Optimal level activity of matrix metalloproteinases is critical for adult visual plasticity in the healthy and stroke-affected brain Pielecka-Fortuna, Justyna Kalogeraki, Evgenia Fortuna, Michal G Löwel, Siegrid eLife Neuroscience The ability of the adult brain to undergo plastic changes is of particular interest in medicine, especially regarding recovery from injuries or improving learning and cognition. Matrix metalloproteinases (MMPs) have been associated with juvenile experience-dependent primary visual cortex (V1) plasticity, yet little is known about their role in this process in the adult V1. Activation of MMPs is a crucial step facilitating structural changes in a healthy brain; however, upon brain injury, upregulated MMPs promote the spread of a lesion and impair recovery. To clarify these seemingly opposing outcomes of MMP-activation, we examined the effects of MMP-inhibition on experience-induced plasticity in healthy and stoke-affected adult mice. In healthy animals, 7-day application of MMP-inhibitor prevented visual plasticity. Additionally, treatment with MMP-inhibitor once but not twice following stroke rescued plasticity, normally lost under these conditions. Our data imply that an optimal level of MMP-activity is crucial for adult visual plasticity to occur. DOI: http://dx.doi.org/10.7554/eLife.11290.001 eLife Sciences Publications, Ltd 2015-11-26 /pmc/articles/PMC4718812/ /pubmed/26609811 http://dx.doi.org/10.7554/eLife.11290 Text en © 2015, Pielecka-Fortuna et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Pielecka-Fortuna, Justyna
Kalogeraki, Evgenia
Fortuna, Michal G
Löwel, Siegrid
Optimal level activity of matrix metalloproteinases is critical for adult visual plasticity in the healthy and stroke-affected brain
title Optimal level activity of matrix metalloproteinases is critical for adult visual plasticity in the healthy and stroke-affected brain
title_full Optimal level activity of matrix metalloproteinases is critical for adult visual plasticity in the healthy and stroke-affected brain
title_fullStr Optimal level activity of matrix metalloproteinases is critical for adult visual plasticity in the healthy and stroke-affected brain
title_full_unstemmed Optimal level activity of matrix metalloproteinases is critical for adult visual plasticity in the healthy and stroke-affected brain
title_short Optimal level activity of matrix metalloproteinases is critical for adult visual plasticity in the healthy and stroke-affected brain
title_sort optimal level activity of matrix metalloproteinases is critical for adult visual plasticity in the healthy and stroke-affected brain
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718812/
https://www.ncbi.nlm.nih.gov/pubmed/26609811
http://dx.doi.org/10.7554/eLife.11290
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