Function of Integrin-Linked Kinase in Modulating the Stemness of IL-6–Abundant Breast Cancer Cells by Regulating γ-Secretase–Mediated Notch1 Activation in Caveolae()()

Interleukin-6 (IL-6) and Notch signaling are important regulators of breast cancer stem cells (CSCs), which drive the malignant phenotype through self-renewal, differentiation, and development of therapeutic resistance. We investigated the role of integrin-linked kinase (ILK) in regulating IL-6–driv...

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Detalles Bibliográficos
Autores principales: Hsu, En-Chi, Kulp, Samuel K., Huang, Han-Li, Tu, Huang-Ju, Salunke, Santosh B., Sullivan, Nicholas J., Sun, Duxin, Wicha, Max S., Shapiro, Charles L., Chen, Ching-Shih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719004/
https://www.ncbi.nlm.nih.gov/pubmed/26152358
http://dx.doi.org/10.1016/j.neo.2015.06.001

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