Myosin IXa Binds AMPAR and Regulates Synaptic Structure, LTP, and Cognitive Function

Myosin IXa (Myo9a) is a motor protein that is highly expressed in the brain. However, the role of Myo9a in neurons remains unknown. Here, we investigated Myo9a function in hippocampal synapses. In rat hippocampal neurons, Myo9a localizes to the postsynaptic density (PSD) and binds the alpha-amino-3-...

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Autores principales: Folci, Alessandra, Murru, Luca, Vezzoli, Elena, Ponzoni, Luisa, Gerosa, Laura, Moretto, Edoardo, Longo, Fabiana, Zapata, Jonathan, Braida, Daniela, Pistillo, Francesco, Bähler, Martin, Francolini, Maura, Sala, Mariaelvina, Bassani, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719083/
https://www.ncbi.nlm.nih.gov/pubmed/26834556
http://dx.doi.org/10.3389/fnmol.2016.00001
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author Folci, Alessandra
Murru, Luca
Vezzoli, Elena
Ponzoni, Luisa
Gerosa, Laura
Moretto, Edoardo
Longo, Fabiana
Zapata, Jonathan
Braida, Daniela
Pistillo, Francesco
Bähler, Martin
Francolini, Maura
Sala, Mariaelvina
Bassani, Silvia
author_facet Folci, Alessandra
Murru, Luca
Vezzoli, Elena
Ponzoni, Luisa
Gerosa, Laura
Moretto, Edoardo
Longo, Fabiana
Zapata, Jonathan
Braida, Daniela
Pistillo, Francesco
Bähler, Martin
Francolini, Maura
Sala, Mariaelvina
Bassani, Silvia
author_sort Folci, Alessandra
collection PubMed
description Myosin IXa (Myo9a) is a motor protein that is highly expressed in the brain. However, the role of Myo9a in neurons remains unknown. Here, we investigated Myo9a function in hippocampal synapses. In rat hippocampal neurons, Myo9a localizes to the postsynaptic density (PSD) and binds the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) GluA2 subunit. Myo9a(+/-) mice displayed a thicker PSD and increased levels of PSD95 and surface AMPAR expression. Furthermore, synaptic transmission, long-term potentiation (LTP) and cognitive functions were impaired in Myo9a(+/-) mice. Together, these results support a key role for Myo9a in controlling the molecular structure and function of hippocampal synapses.
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spelling pubmed-47190832016-01-29 Myosin IXa Binds AMPAR and Regulates Synaptic Structure, LTP, and Cognitive Function Folci, Alessandra Murru, Luca Vezzoli, Elena Ponzoni, Luisa Gerosa, Laura Moretto, Edoardo Longo, Fabiana Zapata, Jonathan Braida, Daniela Pistillo, Francesco Bähler, Martin Francolini, Maura Sala, Mariaelvina Bassani, Silvia Front Mol Neurosci Neuroscience Myosin IXa (Myo9a) is a motor protein that is highly expressed in the brain. However, the role of Myo9a in neurons remains unknown. Here, we investigated Myo9a function in hippocampal synapses. In rat hippocampal neurons, Myo9a localizes to the postsynaptic density (PSD) and binds the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) GluA2 subunit. Myo9a(+/-) mice displayed a thicker PSD and increased levels of PSD95 and surface AMPAR expression. Furthermore, synaptic transmission, long-term potentiation (LTP) and cognitive functions were impaired in Myo9a(+/-) mice. Together, these results support a key role for Myo9a in controlling the molecular structure and function of hippocampal synapses. Frontiers Media S.A. 2016-01-20 /pmc/articles/PMC4719083/ /pubmed/26834556 http://dx.doi.org/10.3389/fnmol.2016.00001 Text en Copyright © 2016 Folci, Murru, Vezzoli, Ponzoni, Gerosa, Moretto, Longo, Zapata, Braida, Pistillo, Bähler, Francolini, Sala and Bassani. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Folci, Alessandra
Murru, Luca
Vezzoli, Elena
Ponzoni, Luisa
Gerosa, Laura
Moretto, Edoardo
Longo, Fabiana
Zapata, Jonathan
Braida, Daniela
Pistillo, Francesco
Bähler, Martin
Francolini, Maura
Sala, Mariaelvina
Bassani, Silvia
Myosin IXa Binds AMPAR and Regulates Synaptic Structure, LTP, and Cognitive Function
title Myosin IXa Binds AMPAR and Regulates Synaptic Structure, LTP, and Cognitive Function
title_full Myosin IXa Binds AMPAR and Regulates Synaptic Structure, LTP, and Cognitive Function
title_fullStr Myosin IXa Binds AMPAR and Regulates Synaptic Structure, LTP, and Cognitive Function
title_full_unstemmed Myosin IXa Binds AMPAR and Regulates Synaptic Structure, LTP, and Cognitive Function
title_short Myosin IXa Binds AMPAR and Regulates Synaptic Structure, LTP, and Cognitive Function
title_sort myosin ixa binds ampar and regulates synaptic structure, ltp, and cognitive function
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719083/
https://www.ncbi.nlm.nih.gov/pubmed/26834556
http://dx.doi.org/10.3389/fnmol.2016.00001
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