On scattered waves and lipid domains: detecting membrane rafts with X-rays and neutrons

In order to understand the biological role of lipids in cell membranes, it is necessary to determine the mesoscopic structure of well-defined model membrane systems. Neutron and X-ray scattering are non-invasive, probe-free techniques that have been used extensively in such systems to probe length s...

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Autores principales: Marquardt, Drew, Heberle, Frederick A., Nickels, Jonathan D., Pabst, Georg, Katsaras, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719199/
https://www.ncbi.nlm.nih.gov/pubmed/26428538
http://dx.doi.org/10.1039/c5sm01807b
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author Marquardt, Drew
Heberle, Frederick A.
Nickels, Jonathan D.
Pabst, Georg
Katsaras, John
author_facet Marquardt, Drew
Heberle, Frederick A.
Nickels, Jonathan D.
Pabst, Georg
Katsaras, John
author_sort Marquardt, Drew
collection PubMed
description In order to understand the biological role of lipids in cell membranes, it is necessary to determine the mesoscopic structure of well-defined model membrane systems. Neutron and X-ray scattering are non-invasive, probe-free techniques that have been used extensively in such systems to probe length scales ranging from angstroms to microns, and dynamics occurring over picosecond to millisecond time scales. Recent developments in the area of phase separated lipid systems mimicking membrane rafts will be presented, and the underlying concepts of the different scattering techniques used to study them will be discussed in detail.
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spelling pubmed-47191992016-02-01 On scattered waves and lipid domains: detecting membrane rafts with X-rays and neutrons Marquardt, Drew Heberle, Frederick A. Nickels, Jonathan D. Pabst, Georg Katsaras, John Soft Matter Chemistry In order to understand the biological role of lipids in cell membranes, it is necessary to determine the mesoscopic structure of well-defined model membrane systems. Neutron and X-ray scattering are non-invasive, probe-free techniques that have been used extensively in such systems to probe length scales ranging from angstroms to microns, and dynamics occurring over picosecond to millisecond time scales. Recent developments in the area of phase separated lipid systems mimicking membrane rafts will be presented, and the underlying concepts of the different scattering techniques used to study them will be discussed in detail. Royal Society of Chemistry 2015-12-21 2015-10-02 /pmc/articles/PMC4719199/ /pubmed/26428538 http://dx.doi.org/10.1039/c5sm01807b Text en This journal is © The Royal Society of Chemistry 2015 http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Marquardt, Drew
Heberle, Frederick A.
Nickels, Jonathan D.
Pabst, Georg
Katsaras, John
On scattered waves and lipid domains: detecting membrane rafts with X-rays and neutrons
title On scattered waves and lipid domains: detecting membrane rafts with X-rays and neutrons
title_full On scattered waves and lipid domains: detecting membrane rafts with X-rays and neutrons
title_fullStr On scattered waves and lipid domains: detecting membrane rafts with X-rays and neutrons
title_full_unstemmed On scattered waves and lipid domains: detecting membrane rafts with X-rays and neutrons
title_short On scattered waves and lipid domains: detecting membrane rafts with X-rays and neutrons
title_sort on scattered waves and lipid domains: detecting membrane rafts with x-rays and neutrons
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719199/
https://www.ncbi.nlm.nih.gov/pubmed/26428538
http://dx.doi.org/10.1039/c5sm01807b
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