Sexually transmitted infections and pre-exposure prophylaxis: challenges and opportunities among men who have sex with men in the US

Pre-Exposure Prophylaxis (PrEP) has shown high efficacy in preventing human immunodeficiency virus (HIV) infection among men who have sex with men (MSM) in several large clinical trials, and more recently in “real world” reports of clinical implementation and a PrEP demonstration project. Those stud...

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Autores principales: Scott, Hyman M., Klausner, Jeffrey D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719214/
https://www.ncbi.nlm.nih.gov/pubmed/26793265
http://dx.doi.org/10.1186/s12981-016-0089-8
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author Scott, Hyman M.
Klausner, Jeffrey D.
author_facet Scott, Hyman M.
Klausner, Jeffrey D.
author_sort Scott, Hyman M.
collection PubMed
description Pre-Exposure Prophylaxis (PrEP) has shown high efficacy in preventing human immunodeficiency virus (HIV) infection among men who have sex with men (MSM) in several large clinical trials, and more recently in “real world” reports of clinical implementation and a PrEP demonstration project. Those studies also demonstrated high bacterial sexually transmitted infection (STI) incidence and raised the discussion of how PrEP may impact STI control efforts, especially in the setting of increasing Neisseria gonorrhoeae antimicrobial resistance and the increase in syphilis cases among MSM. Here, we discuss STIs as a driver of HIV transmission risk among MSM, and the potential opportunities and challenges for STI control afforded by expanded PrEP implementation among high-risk MSM.
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spelling pubmed-47192142016-01-21 Sexually transmitted infections and pre-exposure prophylaxis: challenges and opportunities among men who have sex with men in the US Scott, Hyman M. Klausner, Jeffrey D. AIDS Res Ther Review Pre-Exposure Prophylaxis (PrEP) has shown high efficacy in preventing human immunodeficiency virus (HIV) infection among men who have sex with men (MSM) in several large clinical trials, and more recently in “real world” reports of clinical implementation and a PrEP demonstration project. Those studies also demonstrated high bacterial sexually transmitted infection (STI) incidence and raised the discussion of how PrEP may impact STI control efforts, especially in the setting of increasing Neisseria gonorrhoeae antimicrobial resistance and the increase in syphilis cases among MSM. Here, we discuss STIs as a driver of HIV transmission risk among MSM, and the potential opportunities and challenges for STI control afforded by expanded PrEP implementation among high-risk MSM. BioMed Central 2016-01-19 /pmc/articles/PMC4719214/ /pubmed/26793265 http://dx.doi.org/10.1186/s12981-016-0089-8 Text en © Scott and Klausner. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Scott, Hyman M.
Klausner, Jeffrey D.
Sexually transmitted infections and pre-exposure prophylaxis: challenges and opportunities among men who have sex with men in the US
title Sexually transmitted infections and pre-exposure prophylaxis: challenges and opportunities among men who have sex with men in the US
title_full Sexually transmitted infections and pre-exposure prophylaxis: challenges and opportunities among men who have sex with men in the US
title_fullStr Sexually transmitted infections and pre-exposure prophylaxis: challenges and opportunities among men who have sex with men in the US
title_full_unstemmed Sexually transmitted infections and pre-exposure prophylaxis: challenges and opportunities among men who have sex with men in the US
title_short Sexually transmitted infections and pre-exposure prophylaxis: challenges and opportunities among men who have sex with men in the US
title_sort sexually transmitted infections and pre-exposure prophylaxis: challenges and opportunities among men who have sex with men in the us
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719214/
https://www.ncbi.nlm.nih.gov/pubmed/26793265
http://dx.doi.org/10.1186/s12981-016-0089-8
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