Higher expression of TNFα-induced genes in the synovium of patients with early rheumatoid arthritis correlates with disease activity, and predicts absence of response to first line therapy

BACKGROUND: IL6-related T cell activation and TNFα-dependent cell proliferation are major targets of therapy in the RA synovium. We investigated whether expression of these pathways in RA synovial biopsies is associated with disease activity and response to therapy. METHOD: Correlation and gene set...

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Detalles Bibliográficos
Autores principales: De Groof, Aurélie, Ducreux, Julie, Humby, Frances, Nzeusseu Toukap, Adrien, Badot, Valérie, Pitzalis, Costantino, Houssiau, Frédéric A., Durez, Patrick, Lauwerys, Bernard R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719339/
https://www.ncbi.nlm.nih.gov/pubmed/26792343
http://dx.doi.org/10.1186/s13075-016-0919-z

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