Cargando…
Exploring Bhavana samskara using Tinospora cordifolia and Phyllanthus emblica combination for learning and memory in mice
BACKGROUND: Current medications for dementia and enhancement of learning and memory are limited hence we need to explore traditional medicinal systems like Ayurveda to investigate agents that can improve learning and enhance memory. OBJECTIVE: The present study was carried out to evaluate effects an...
Autor principal: | |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719483/ https://www.ncbi.nlm.nih.gov/pubmed/26834422 http://dx.doi.org/10.4103/0975-9476.157953 |
_version_ | 1782410939193098240 |
---|---|
author | Malve, Harshad Onkarrao |
author_facet | Malve, Harshad Onkarrao |
author_sort | Malve, Harshad Onkarrao |
collection | PubMed |
description | BACKGROUND: Current medications for dementia and enhancement of learning and memory are limited hence we need to explore traditional medicinal systems like Ayurveda to investigate agents that can improve learning and enhance memory. OBJECTIVE: The present study was carried out to evaluate effects and mechanisms of Ayurveda drug formulations, Tinospora cordifolia (Tc) and Phyllanthus emblica (Pe) with and without Bhavana samskara on learning and memory of mice. MATERIALS AND METHODS: After approval of Animal Ethics Committee, Swiss albino mice were divided into seven groups, administered orally: Distilled water, Rivastigmine (2.4 mg/kg), Tc (100 mg/kg), Pe (300 mg/kg), 1 formulation (Tc + Pe: 400 mg/kg) and formulation 2 (Tc + Pe + Ocimum sanctum: 400 mg/kg) daily for 15 days. Piracetam (200 mg/kg) was injected daily intraperitoneally for 8 days. The mice underwent a learning session using elevated plus maze. Memory was tested 24 hours later. RESULTS: Mice pretreated with all the drugs showed a trend toward reducing transfer latencies but values were comparable to vehicle control. In all drug-treated groups, a significant reduction in transfer latency was observed after 24 h. Improvement in learning and memory by both formulations were comparable to individual plant drugs, Tc and Pe. CONCLUSION: The plant drugs showed improvements in learning and memory. The fixed-dose formulations with Bhavana samskara, showed encouraging results as compared to individual agents but the difference was not statistically significant. Hence, the concept of Bhavana samskara could not be explored in the present study. However, these drugs showed comparable or better effects than the modern medicinal agents thus, their therapeutic potential as nootropics needs to be explored further. |
format | Online Article Text |
id | pubmed-4719483 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-47194832016-02-01 Exploring Bhavana samskara using Tinospora cordifolia and Phyllanthus emblica combination for learning and memory in mice Malve, Harshad Onkarrao J Ayurveda Integr Med Original Research Article BACKGROUND: Current medications for dementia and enhancement of learning and memory are limited hence we need to explore traditional medicinal systems like Ayurveda to investigate agents that can improve learning and enhance memory. OBJECTIVE: The present study was carried out to evaluate effects and mechanisms of Ayurveda drug formulations, Tinospora cordifolia (Tc) and Phyllanthus emblica (Pe) with and without Bhavana samskara on learning and memory of mice. MATERIALS AND METHODS: After approval of Animal Ethics Committee, Swiss albino mice were divided into seven groups, administered orally: Distilled water, Rivastigmine (2.4 mg/kg), Tc (100 mg/kg), Pe (300 mg/kg), 1 formulation (Tc + Pe: 400 mg/kg) and formulation 2 (Tc + Pe + Ocimum sanctum: 400 mg/kg) daily for 15 days. Piracetam (200 mg/kg) was injected daily intraperitoneally for 8 days. The mice underwent a learning session using elevated plus maze. Memory was tested 24 hours later. RESULTS: Mice pretreated with all the drugs showed a trend toward reducing transfer latencies but values were comparable to vehicle control. In all drug-treated groups, a significant reduction in transfer latency was observed after 24 h. Improvement in learning and memory by both formulations were comparable to individual plant drugs, Tc and Pe. CONCLUSION: The plant drugs showed improvements in learning and memory. The fixed-dose formulations with Bhavana samskara, showed encouraging results as compared to individual agents but the difference was not statistically significant. Hence, the concept of Bhavana samskara could not be explored in the present study. However, these drugs showed comparable or better effects than the modern medicinal agents thus, their therapeutic potential as nootropics needs to be explored further. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4719483/ /pubmed/26834422 http://dx.doi.org/10.4103/0975-9476.157953 Text en Copyright: © Journal of Ayurveda and Integrative Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Research Article Malve, Harshad Onkarrao Exploring Bhavana samskara using Tinospora cordifolia and Phyllanthus emblica combination for learning and memory in mice |
title | Exploring Bhavana samskara using Tinospora cordifolia and Phyllanthus emblica combination for learning and memory in mice |
title_full | Exploring Bhavana samskara using Tinospora cordifolia and Phyllanthus emblica combination for learning and memory in mice |
title_fullStr | Exploring Bhavana samskara using Tinospora cordifolia and Phyllanthus emblica combination for learning and memory in mice |
title_full_unstemmed | Exploring Bhavana samskara using Tinospora cordifolia and Phyllanthus emblica combination for learning and memory in mice |
title_short | Exploring Bhavana samskara using Tinospora cordifolia and Phyllanthus emblica combination for learning and memory in mice |
title_sort | exploring bhavana samskara using tinospora cordifolia and phyllanthus emblica combination for learning and memory in mice |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719483/ https://www.ncbi.nlm.nih.gov/pubmed/26834422 http://dx.doi.org/10.4103/0975-9476.157953 |
work_keys_str_mv | AT malveharshadonkarrao exploringbhavanasamskarausingtinosporacordifoliaandphyllanthusemblicacombinationforlearningandmemoryinmice |