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Thai generic-brand dry canine foods: mutagenicity and the effects of feeding in vivo and in vitro

BACKGROUND: The commercial pet-food industry and the market value of the pet industry have increased. Most owners are concerned about their pets’ health, and prefer commercial pet foods as their regular diet. This study thus aimed to determine whether a selection of local generic-brand dry canine fo...

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Autores principales: Khuntamoon, Tanyalak, Thepouyporn, Apanchanid, Kaewprasert, Sarunya, Prangthip, Pattaneeya, Pooudoung, Somchai, Chaisri, Urai, Maneesai, Phudit, Kwanbunjan, Karunee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719534/
https://www.ncbi.nlm.nih.gov/pubmed/26785914
http://dx.doi.org/10.1186/s12917-016-0640-9
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author Khuntamoon, Tanyalak
Thepouyporn, Apanchanid
Kaewprasert, Sarunya
Prangthip, Pattaneeya
Pooudoung, Somchai
Chaisri, Urai
Maneesai, Phudit
Kwanbunjan, Karunee
author_facet Khuntamoon, Tanyalak
Thepouyporn, Apanchanid
Kaewprasert, Sarunya
Prangthip, Pattaneeya
Pooudoung, Somchai
Chaisri, Urai
Maneesai, Phudit
Kwanbunjan, Karunee
author_sort Khuntamoon, Tanyalak
collection PubMed
description BACKGROUND: The commercial pet-food industry and the market value of the pet industry have increased. Most owners are concerned about their pets’ health, and prefer commercial pet foods as their regular diet. This study thus aimed to determine whether a selection of local generic-brand dry canine foods had any potential to promote chronic disease. METHODS: Five local, generic-brand, dry canine foods were studied for potential mutagenicity; the effects of long-term consumption were also observed in rats. All canine foods were extracted with distilled water and absolute ethanol. The Ames test was used to detect short-term genetic damage, using Salmonella typhimurium tester strains TA98 and TA100. Simultaneously, the long-term effects were studied in an animal model by observing rats fed with these canine foods, compared with normal rat food, for a period of 15 weeks. RESULTS: Using the water extracts, all dry canine foods studied showed considerable mutagenic effects on the tester strains. One brand affected both tester strains, whereas 3 showed positive to TA98, and one to TA100. With the absolute ethanol extract, three of the five brands had a considerable mutagenic effect on TA98, and another affected TA100. In the long-term test, all rats remained alive until the end of the experiment, exhibited no apparent signs of toxicity or serious illness, and maintained normal bodyweight and weight gain. Serum blood biochemistry and hematological parameters in canine food-fed rats showed some negative effects. Correspondingly, histopathological investigation of their liver and kidneys showed deterioration. CONCLUSIONS: Mutagenic potential and the negative potential health impacts were observed in all local-brand dry canine foods tested.
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spelling pubmed-47195342016-01-21 Thai generic-brand dry canine foods: mutagenicity and the effects of feeding in vivo and in vitro Khuntamoon, Tanyalak Thepouyporn, Apanchanid Kaewprasert, Sarunya Prangthip, Pattaneeya Pooudoung, Somchai Chaisri, Urai Maneesai, Phudit Kwanbunjan, Karunee BMC Vet Res Research Article BACKGROUND: The commercial pet-food industry and the market value of the pet industry have increased. Most owners are concerned about their pets’ health, and prefer commercial pet foods as their regular diet. This study thus aimed to determine whether a selection of local generic-brand dry canine foods had any potential to promote chronic disease. METHODS: Five local, generic-brand, dry canine foods were studied for potential mutagenicity; the effects of long-term consumption were also observed in rats. All canine foods were extracted with distilled water and absolute ethanol. The Ames test was used to detect short-term genetic damage, using Salmonella typhimurium tester strains TA98 and TA100. Simultaneously, the long-term effects were studied in an animal model by observing rats fed with these canine foods, compared with normal rat food, for a period of 15 weeks. RESULTS: Using the water extracts, all dry canine foods studied showed considerable mutagenic effects on the tester strains. One brand affected both tester strains, whereas 3 showed positive to TA98, and one to TA100. With the absolute ethanol extract, three of the five brands had a considerable mutagenic effect on TA98, and another affected TA100. In the long-term test, all rats remained alive until the end of the experiment, exhibited no apparent signs of toxicity or serious illness, and maintained normal bodyweight and weight gain. Serum blood biochemistry and hematological parameters in canine food-fed rats showed some negative effects. Correspondingly, histopathological investigation of their liver and kidneys showed deterioration. CONCLUSIONS: Mutagenic potential and the negative potential health impacts were observed in all local-brand dry canine foods tested. BioMed Central 2016-01-20 /pmc/articles/PMC4719534/ /pubmed/26785914 http://dx.doi.org/10.1186/s12917-016-0640-9 Text en © Khuntamoon et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Khuntamoon, Tanyalak
Thepouyporn, Apanchanid
Kaewprasert, Sarunya
Prangthip, Pattaneeya
Pooudoung, Somchai
Chaisri, Urai
Maneesai, Phudit
Kwanbunjan, Karunee
Thai generic-brand dry canine foods: mutagenicity and the effects of feeding in vivo and in vitro
title Thai generic-brand dry canine foods: mutagenicity and the effects of feeding in vivo and in vitro
title_full Thai generic-brand dry canine foods: mutagenicity and the effects of feeding in vivo and in vitro
title_fullStr Thai generic-brand dry canine foods: mutagenicity and the effects of feeding in vivo and in vitro
title_full_unstemmed Thai generic-brand dry canine foods: mutagenicity and the effects of feeding in vivo and in vitro
title_short Thai generic-brand dry canine foods: mutagenicity and the effects of feeding in vivo and in vitro
title_sort thai generic-brand dry canine foods: mutagenicity and the effects of feeding in vivo and in vitro
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719534/
https://www.ncbi.nlm.nih.gov/pubmed/26785914
http://dx.doi.org/10.1186/s12917-016-0640-9
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