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Crystal structure of 7-{[bis(pyridin-2-ylmethyl)amino]methyl}-5-chloroquinolin-8-ol
In the title compound, C(22)H(19)ClN(4)O, the quinolinol moiety is almost planar [r.m.s. deviation = 0.012 Å]. There is an intramolecular O—H⋯N hydrogen bond involving the hydroxy group and a pyridine N atom forming an S(9) ring motif. The dihedral angles between the planes of the quinolinol moiet...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719835/ https://www.ncbi.nlm.nih.gov/pubmed/26870426 http://dx.doi.org/10.1107/S2056989015022410 |
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author | Kubono, Koji Kado, Kimiko Kashiwagi, Yukiyasu Tani, Keita Yokoi, Kunihiko |
author_facet | Kubono, Koji Kado, Kimiko Kashiwagi, Yukiyasu Tani, Keita Yokoi, Kunihiko |
author_sort | Kubono, Koji |
collection | PubMed |
description | In the title compound, C(22)H(19)ClN(4)O, the quinolinol moiety is almost planar [r.m.s. deviation = 0.012 Å]. There is an intramolecular O—H⋯N hydrogen bond involving the hydroxy group and a pyridine N atom forming an S(9) ring motif. The dihedral angles between the planes of the quinolinol moiety and the pyridine rings are 44.15 (9) and 36.85 (9)°. In the crystal, molecules are linked via C—H⋯O hydrogen bonds forming inversion dimers with an R (4) (4)(10) ring motif. The dimers are linked by C—H⋯N hydrogen bonds, forming ribbons along [01-1]. The ribbons are linked by C—H⋯π and π–π interactions [inter-centroid distance = 3.7109 (11) Å], forming layers parallel to (01-1). |
format | Online Article Text |
id | pubmed-4719835 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | International Union of Crystallography |
record_format | MEDLINE/PubMed |
spelling | pubmed-47198352016-02-11 Crystal structure of 7-{[bis(pyridin-2-ylmethyl)amino]methyl}-5-chloroquinolin-8-ol Kubono, Koji Kado, Kimiko Kashiwagi, Yukiyasu Tani, Keita Yokoi, Kunihiko Acta Crystallogr E Crystallogr Commun Research Communications In the title compound, C(22)H(19)ClN(4)O, the quinolinol moiety is almost planar [r.m.s. deviation = 0.012 Å]. There is an intramolecular O—H⋯N hydrogen bond involving the hydroxy group and a pyridine N atom forming an S(9) ring motif. The dihedral angles between the planes of the quinolinol moiety and the pyridine rings are 44.15 (9) and 36.85 (9)°. In the crystal, molecules are linked via C—H⋯O hydrogen bonds forming inversion dimers with an R (4) (4)(10) ring motif. The dimers are linked by C—H⋯N hydrogen bonds, forming ribbons along [01-1]. The ribbons are linked by C—H⋯π and π–π interactions [inter-centroid distance = 3.7109 (11) Å], forming layers parallel to (01-1). International Union of Crystallography 2015-11-28 /pmc/articles/PMC4719835/ /pubmed/26870426 http://dx.doi.org/10.1107/S2056989015022410 Text en © Kubono et al. 2015 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
spellingShingle | Research Communications Kubono, Koji Kado, Kimiko Kashiwagi, Yukiyasu Tani, Keita Yokoi, Kunihiko Crystal structure of 7-{[bis(pyridin-2-ylmethyl)amino]methyl}-5-chloroquinolin-8-ol |
title | Crystal structure of 7-{[bis(pyridin-2-ylmethyl)amino]methyl}-5-chloroquinolin-8-ol |
title_full | Crystal structure of 7-{[bis(pyridin-2-ylmethyl)amino]methyl}-5-chloroquinolin-8-ol |
title_fullStr | Crystal structure of 7-{[bis(pyridin-2-ylmethyl)amino]methyl}-5-chloroquinolin-8-ol |
title_full_unstemmed | Crystal structure of 7-{[bis(pyridin-2-ylmethyl)amino]methyl}-5-chloroquinolin-8-ol |
title_short | Crystal structure of 7-{[bis(pyridin-2-ylmethyl)amino]methyl}-5-chloroquinolin-8-ol |
title_sort | crystal structure of 7-{[bis(pyridin-2-ylmethyl)amino]methyl}-5-chloroquinolin-8-ol |
topic | Research Communications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719835/ https://www.ncbi.nlm.nih.gov/pubmed/26870426 http://dx.doi.org/10.1107/S2056989015022410 |
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