Enhanced ex vivo intestinal absorption of olmesartan medoxomil nanosuspension: Preparation by combinative technology

The purpose of this study was to develop nanosuspension based on combinative technology to enhance the intestinal absorption of Olmesartan medoxomil (OLM), a potent antihypertensive agent with limited oral bioavailability. Two combinative approaches were employed and then characterized. In vitro int...

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Detalles Bibliográficos
Autores principales: Attari, Zenab, Bhandari, Amita, Jagadish, P.C., Lewis, Shaila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720021/
https://www.ncbi.nlm.nih.gov/pubmed/26903769
http://dx.doi.org/10.1016/j.jsps.2015.03.008
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author Attari, Zenab
Bhandari, Amita
Jagadish, P.C.
Lewis, Shaila
author_facet Attari, Zenab
Bhandari, Amita
Jagadish, P.C.
Lewis, Shaila
author_sort Attari, Zenab
collection PubMed
description The purpose of this study was to develop nanosuspension based on combinative technology to enhance the intestinal absorption of Olmesartan medoxomil (OLM), a potent antihypertensive agent with limited oral bioavailability. Two combinative approaches were employed and then characterized. In vitro intestinal absorption of OLM nanosuspension and plain OLM was studied using non-everted rat intestinal sac model. Optimal OLM nanosuspension was prepared by a combination of ball milling and probe sonication using stabilizer, Poloxamer 407. The formula exhibited particle size of 469.9 nm and zeta potential of −19.1 mV, which was subjected to ex vivo studies. The flux and apparent permeability coefficient in intestine from OLM nanosuspension was higher than the plain drug, thereby suggesting better drug delivery.
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spelling pubmed-47200212016-02-22 Enhanced ex vivo intestinal absorption of olmesartan medoxomil nanosuspension: Preparation by combinative technology Attari, Zenab Bhandari, Amita Jagadish, P.C. Lewis, Shaila Saudi Pharm J Original Article The purpose of this study was to develop nanosuspension based on combinative technology to enhance the intestinal absorption of Olmesartan medoxomil (OLM), a potent antihypertensive agent with limited oral bioavailability. Two combinative approaches were employed and then characterized. In vitro intestinal absorption of OLM nanosuspension and plain OLM was studied using non-everted rat intestinal sac model. Optimal OLM nanosuspension was prepared by a combination of ball milling and probe sonication using stabilizer, Poloxamer 407. The formula exhibited particle size of 469.9 nm and zeta potential of −19.1 mV, which was subjected to ex vivo studies. The flux and apparent permeability coefficient in intestine from OLM nanosuspension was higher than the plain drug, thereby suggesting better drug delivery. Elsevier 2016-01 2015-03-20 /pmc/articles/PMC4720021/ /pubmed/26903769 http://dx.doi.org/10.1016/j.jsps.2015.03.008 Text en © 2015 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Attari, Zenab
Bhandari, Amita
Jagadish, P.C.
Lewis, Shaila
Enhanced ex vivo intestinal absorption of olmesartan medoxomil nanosuspension: Preparation by combinative technology
title Enhanced ex vivo intestinal absorption of olmesartan medoxomil nanosuspension: Preparation by combinative technology
title_full Enhanced ex vivo intestinal absorption of olmesartan medoxomil nanosuspension: Preparation by combinative technology
title_fullStr Enhanced ex vivo intestinal absorption of olmesartan medoxomil nanosuspension: Preparation by combinative technology
title_full_unstemmed Enhanced ex vivo intestinal absorption of olmesartan medoxomil nanosuspension: Preparation by combinative technology
title_short Enhanced ex vivo intestinal absorption of olmesartan medoxomil nanosuspension: Preparation by combinative technology
title_sort enhanced ex vivo intestinal absorption of olmesartan medoxomil nanosuspension: preparation by combinative technology
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720021/
https://www.ncbi.nlm.nih.gov/pubmed/26903769
http://dx.doi.org/10.1016/j.jsps.2015.03.008
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