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Allosteric modulation of metabotropic glutamate receptor 4 activates IDO1-dependent, immunoregulatory signaling in dendritic cells

Metabotropic glutamate receptor 4 (mGluR4) possesses immune modulatory properties in vivo, such that a positive allosteric modulator (PAM) of the receptor confers protection on mice with relapsing-remitting experimental autoimmune encephalomyelitis (RR-EAE). ADX88178 is a newly-developed, one such m...

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Detalles Bibliográficos
Autores principales:	Volpi, Claudia, Mondanelli, Giada, Pallotta, Maria T., Vacca, Carmine, Iacono, Alberta, Gargaro, Marco, Albini, Elisa, Bianchi, Roberta, Belladonna, Maria L., Celanire, Sylvain, Mordant, Céline, Heroux, Madeleine, Royer-Urios, Isabelle, Schneider, Manfred, Vitte, Pierre-Alain, Cacquevel, Mathias, Galibert, Laurent, Poli, Sonia-Maria, Solari, Aldo, Bicciato, Silvio, Calvitti, Mario, Antognelli, Cinzia, Puccetti, Paolo, Orabona, Ciriana, Fallarino, Francesca, Grohmann, Ursula
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Pergamon Press 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720030/ https://www.ncbi.nlm.nih.gov/pubmed/26522434 http://dx.doi.org/10.1016/j.neuropharm.2015.10.036

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