N-Methylation as a Strategy for Enhancing the Affinity and Selectivity of RNA-binding Peptides: Application to the HIV-1 Frameshift-Stimulating RNA

[Image: see text] Human Immunodeficiency Virus (HIV) type 1 uses a −1 programmed ribosomal frameshift (−1 PRF) event to translate its enzymes from the same transcript used to encode the virus’ structural proteins. The frequency of this event is highly regulated, and significant deviation from the no...

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Detalles Bibliográficos
Autores principales: Hilimire, Thomas A., Bennett, Ryan P., Stewart, Ryan A., Garcia-Miranda, Pablo, Blume, Alex, Becker, Jordan, Sherer, Nathan, Helms, Eric D., Butcher, Samuel E., Smith, Harold C., Miller, Benjamin L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720131/
https://www.ncbi.nlm.nih.gov/pubmed/26496521
http://dx.doi.org/10.1021/acschembio.5b00682

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