An Effective Bifunctional Aldehyde Linchpin for Type II Anion Relay Chemistry: Development and Application to the Synthesis of a C16–C29 Fragment of Rhizopodin

[Image: see text] The design, synthesis, and validation of a new bifunctional aldehyde linchpin for Type II anion relay chemistry have been achieved. For this linchpin, the initial nucleophilic addition proceeds under Felkin–Anh control to generate the syn-alkoxide, which undergoes a 1,4-Brook rearr...

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Detalles Bibliográficos
Autores principales: Melillo, Bruno, Chen, Ming Z., Forestieri, Roberto, Smith, Amos B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720133/
https://www.ncbi.nlm.nih.gov/pubmed/26641664
http://dx.doi.org/10.1021/acs.orglett.5b03235

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720133/
https://www.ncbi.nlm.nih.gov/pubmed/26641664
http://dx.doi.org/10.1021/acs.orglett.5b03235

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