Post-streptococcal glomerulonephritis associated with atypical hemolytic uremic syndrome: to treat or not to treat with eculizumab?

A 7-year-old male with poststreptococcal glomerulonephritis (PSGN) developed hemolytic uremic syndrome (HUS) and achieved remission. He was treated with eculizumab for 1 year. The eculizumab was discontinued and the patient remained in remission. This is the 10th reported case of PSGN associated wit...

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Autores principales: Kakajiwala, Aadil, Bhatti, Tricia, Kaplan, Bernard S., Ruebner, Rebecca L., Copelovitch, Lawrence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Glomerulonephritis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720198/
https://www.ncbi.nlm.nih.gov/pubmed/26798467
http://dx.doi.org/10.1093/ckj/sfv119
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author Kakajiwala, Aadil
Bhatti, Tricia
Kaplan, Bernard S.
Ruebner, Rebecca L.
Copelovitch, Lawrence
author_facet Kakajiwala, Aadil
Bhatti, Tricia
Kaplan, Bernard S.
Ruebner, Rebecca L.
Copelovitch, Lawrence
author_sort Kakajiwala, Aadil
collection PubMed
description A 7-year-old male with poststreptococcal glomerulonephritis (PSGN) developed hemolytic uremic syndrome (HUS) and achieved remission. He was treated with eculizumab for 1 year. The eculizumab was discontinued and the patient remained in remission. This is the 10th reported case of PSGN associated with HUS. The histopathological feature observed at the 1-year follow-up was indistinguishable from the expected findings in an individual with healed PSGN without associated HUS. The relatively good prognosis in most prior cases and the absence of any reported recurrences strongly suggest that this form of atypical HUS does not warrant long-term eculizumab therapy.
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spelling pubmed-47201982016-01-21 Post-streptococcal glomerulonephritis associated with atypical hemolytic uremic syndrome: to treat or not to treat with eculizumab? Kakajiwala, Aadil Bhatti, Tricia Kaplan, Bernard S. Ruebner, Rebecca L. Copelovitch, Lawrence Clin Kidney J Glomerulonephritis A 7-year-old male with poststreptococcal glomerulonephritis (PSGN) developed hemolytic uremic syndrome (HUS) and achieved remission. He was treated with eculizumab for 1 year. The eculizumab was discontinued and the patient remained in remission. This is the 10th reported case of PSGN associated with HUS. The histopathological feature observed at the 1-year follow-up was indistinguishable from the expected findings in an individual with healed PSGN without associated HUS. The relatively good prognosis in most prior cases and the absence of any reported recurrences strongly suggest that this form of atypical HUS does not warrant long-term eculizumab therapy. Oxford University Press 2016-02 2015-11-26 /pmc/articles/PMC4720198/ /pubmed/26798467 http://dx.doi.org/10.1093/ckj/sfv119 Text en © The Author 2015. Published by Oxford University Press on behalf of ERA-EDTA. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Glomerulonephritis
Kakajiwala, Aadil
Bhatti, Tricia
Kaplan, Bernard S.
Ruebner, Rebecca L.
Copelovitch, Lawrence
Post-streptococcal glomerulonephritis associated with atypical hemolytic uremic syndrome: to treat or not to treat with eculizumab?
title Post-streptococcal glomerulonephritis associated with atypical hemolytic uremic syndrome: to treat or not to treat with eculizumab?
title_full Post-streptococcal glomerulonephritis associated with atypical hemolytic uremic syndrome: to treat or not to treat with eculizumab?
title_fullStr Post-streptococcal glomerulonephritis associated with atypical hemolytic uremic syndrome: to treat or not to treat with eculizumab?
title_full_unstemmed Post-streptococcal glomerulonephritis associated with atypical hemolytic uremic syndrome: to treat or not to treat with eculizumab?
title_short Post-streptococcal glomerulonephritis associated with atypical hemolytic uremic syndrome: to treat or not to treat with eculizumab?
title_sort post-streptococcal glomerulonephritis associated with atypical hemolytic uremic syndrome: to treat or not to treat with eculizumab?
topic Glomerulonephritis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720198/
https://www.ncbi.nlm.nih.gov/pubmed/26798467
http://dx.doi.org/10.1093/ckj/sfv119
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