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Dasatinib Reduces Lung Inflammation and Fibrosis in Acute Experimental Silicosis
Silicosis is an occupational lung disease with no effective treatment. We hypothesized that dasatinib, a tyrosine kinase inhibitor, might exhibit therapeutic efficacy in silica-induced pulmonary fibrosis. Silicosis was induced in C57BL/6 mice by a single intratracheal administration of silica partic...
Autores principales: | Cruz, Fernanda Ferreira, Horta, Lucas Felipe Bastos, Maia, Lígia de Albuquerque, Lopes-Pacheco, Miquéias, da Silva, André Benedito, Morales, Marcelo Marco, Gonçalves-de-Albuquerque, Cassiano Felippe, Takiya, Christina Maeda, de Castro-Faria-Neto, Hugo Caire, Rocco, Patricia Rieken Macedo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720427/ https://www.ncbi.nlm.nih.gov/pubmed/26789403 http://dx.doi.org/10.1371/journal.pone.0147005 |
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