Interleukin-22 Promotes Intestinal Stem Cell-Mediated Epithelial Regeneration

Epithelial regeneration is critical for barrier maintenance and organ function after intestinal injury. The intestinal stem cell (ISC) niche provides Wnt, Notch, and epidermal growth factor (EGF) signals supporting Lgr5(+) crypt base columnar ISCs for normal epithelial maintenance(1,2). However, lit...

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Detalles Bibliográficos
Autores principales: Lindemans, Caroline A., Calafiore, Marco, Mertelsmann, Anna M., O'Connor, Margaret H., Dudakov, Jarrod A., Jenq, Robert R., Velardi, Enrico, Young, Lauren F., Smith, Odette M., Lawrence, Gillian, Ivanov, Juliet A., Fu, Ya-Yuan, Takashima, Shuichiro, Hua, Guoqiang, Martin, Maria L., O'Rourke, Kevin P., Lo, Yuan-Hung, Mokry, Michal, Romera-Hernandez, Monica, Cupedo, Tom, Dow, Lukas, Nieuwenhuis, Edward E., Shroyer, Noah F., Liu, Chen, Kolesnick, Richard, van den Brink, Marcel R.M., Hanash, Alan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720437/
https://www.ncbi.nlm.nih.gov/pubmed/26649819
http://dx.doi.org/10.1038/nature16460

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