Drug-drug interactions in older patients with cancer: a report from the 15th Conference of the International Society of Geriatric Oncology, Prague, Czech Republic, November 2015

Drugs taken for cancer can interact with each other, with agents taken as part of supportive care, with drugs taken for comorbid conditions (which are particularly common in the elderly patients), and with herbal supplements and complementary medicines. We tend to focus on the narrow therapeutic win...

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Detalles Bibliográficos
Autores principales: Stepney, Rob, Lichtman, Stuart M, Danesi, Romano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cancer Intelligence 2016
Materias:
Conference Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720490/
https://www.ncbi.nlm.nih.gov/pubmed/26823680
http://dx.doi.org/10.3332/ecancer.2016.611
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author Stepney, Rob
Lichtman, Stuart M
Danesi, Romano
author_facet Stepney, Rob
Lichtman, Stuart M
Danesi, Romano
author_sort Stepney, Rob
collection PubMed
description Drugs taken for cancer can interact with each other, with agents taken as part of supportive care, with drugs taken for comorbid conditions (which are particularly common in the elderly patients), and with herbal supplements and complementary medicines. We tend to focus on the narrow therapeutic window of cytotoxics, but the metabolism of tyrosine kinase inhibitors by the cytochrome P450 3A4 enzyme (CYP3A4) makes some TKIs particularly prone to interference with or from other agents sharing this pathway. There is also potential for adverse pharmacokinetic interactions with new hormonal agents used in advanced prostate cancer.
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spelling pubmed-47204902016-01-28 Drug-drug interactions in older patients with cancer: a report from the 15th Conference of the International Society of Geriatric Oncology, Prague, Czech Republic, November 2015 Stepney, Rob Lichtman, Stuart M Danesi, Romano Ecancermedicalscience Conference Report Drugs taken for cancer can interact with each other, with agents taken as part of supportive care, with drugs taken for comorbid conditions (which are particularly common in the elderly patients), and with herbal supplements and complementary medicines. We tend to focus on the narrow therapeutic window of cytotoxics, but the metabolism of tyrosine kinase inhibitors by the cytochrome P450 3A4 enzyme (CYP3A4) makes some TKIs particularly prone to interference with or from other agents sharing this pathway. There is also potential for adverse pharmacokinetic interactions with new hormonal agents used in advanced prostate cancer. Cancer Intelligence 2016-01-14 /pmc/articles/PMC4720490/ /pubmed/26823680 http://dx.doi.org/10.3332/ecancer.2016.611 Text en © the authors; licensee ecancermedicalscience. http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Conference Report
Stepney, Rob
Lichtman, Stuart M
Danesi, Romano
Drug-drug interactions in older patients with cancer: a report from the 15th Conference of the International Society of Geriatric Oncology, Prague, Czech Republic, November 2015
title Drug-drug interactions in older patients with cancer: a report from the 15th Conference of the International Society of Geriatric Oncology, Prague, Czech Republic, November 2015
title_full Drug-drug interactions in older patients with cancer: a report from the 15th Conference of the International Society of Geriatric Oncology, Prague, Czech Republic, November 2015
title_fullStr Drug-drug interactions in older patients with cancer: a report from the 15th Conference of the International Society of Geriatric Oncology, Prague, Czech Republic, November 2015
title_full_unstemmed Drug-drug interactions in older patients with cancer: a report from the 15th Conference of the International Society of Geriatric Oncology, Prague, Czech Republic, November 2015
title_short Drug-drug interactions in older patients with cancer: a report from the 15th Conference of the International Society of Geriatric Oncology, Prague, Czech Republic, November 2015
title_sort drug-drug interactions in older patients with cancer: a report from the 15th conference of the international society of geriatric oncology, prague, czech republic, november 2015
topic Conference Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720490/
https://www.ncbi.nlm.nih.gov/pubmed/26823680
http://dx.doi.org/10.3332/ecancer.2016.611
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