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Calcium Handling by Endoplasmic Reticulum and Mitochondria in a Cell Model of Huntington’s Disease
Huntington disease (HD) is caused by the CAG (Q) expansion in exon 1 of the IT15 gene encoding a polyglutamine (poly-Q) stretch of the Huntingtin protein (Htt). In the wild type protein, the repeats specify a stretch of up 34 Q in the N-terminal portion of Htt. In the pathological protein (mHtt) the...
Autores principales: | De Mario, Agnese, Scarlatti, Chiara, Costiniti, Veronica, Primerano, Simona, Lopreiato, Raffaele, Calì, Tito, Brini, Marisa, Giacomello, Marta, Carafoli, Ernesto |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720599/ https://www.ncbi.nlm.nih.gov/pubmed/26819834 http://dx.doi.org/10.1371/currents.hd.37fcb1c9a27503dc845594ee4a7316c3 |
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