Cargando…

Akt inhibition attenuates rasfonin-induced autophagy and apoptosis through the glycolytic pathway in renal cancer cells

Rasfonin is a fungal secondary metabolite with demonstrated antitumor effects. However, the underlying mechanism of the regulatory role in autophagy initiated by rasfonin is largely unknown. Moreover, the function of Akt to positively mediate the induced autophagy remains elusive. In the present stu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lu, Q, Yan, S, Sun, H, Wang, W, Li, Y, Yang, X, Jiang, X, Che, Y, Xi, Z
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720880/ https://www.ncbi.nlm.nih.gov/pubmed/26633711 http://dx.doi.org/10.1038/cddis.2015.344

Ejemplares similares

Proteasome inhibition attenuates rasfonin-induced autophagy concurring with the upregulation of caspase-dependent apoptosis
por: Yan, Siyuan, et al.
Publicado: (2016)

AB44. Akt inhibition attenuates rasfonin (A304)-induced autophagy and casapase-dependent apoptosis via mTOR complex signaling in renal cancer cells
por: Xi, Zhijun
Publicado: (2014)

Fungal secondary metabolites rasfonin induces autophagy, apoptosis and necroptosis in renal cancer cell line
por: Sun, Hui, et al.
Publicado: (2016)

Rasfonin promotes autophagy and apoptosis via upregulation of reactive oxygen species (ROS)/JNK pathway
por: Wang, Weijun, et al.
Publicado: (2016)

Grb2 interacts with necrosome components and is involved in rasfonin-induced necroptosis
por: Hou, Bolin, et al.
Publicado: (2022)

Rasfonin, a novel 2-pyrone derivative, induces ras-mutated Panc-1 pancreatic tumor cell death in nude mice
por: Xiao, Z, et al.
Publicado: (2014)

Genome analysis of Cephalotrichum gorgonifer and identification of the biosynthetic pathway for rasfonin, an inhibitor of KRAS dependent cancer
por: Schüller, Andreas, et al.
Publicado: (2023)

Liraglutide inhibits autophagy and apoptosis induced by high glucose through GLP-1R in renal tubular epithelial cells
por: ZHAO, X, et al.
Publicado: (2015)

Quercetin postconditioning attenuates myocardial ischemia/reperfusion injury in rats through the PI3K/Akt pathway
por: Wang, Y., et al.
Publicado: (2013)

BRCC2 inhibits breast cancer cell growth and metastasis in vitro and in vivo via downregulating AKT pathway
por: Li, X, et al.
Publicado: (2013)

Eicosapentaenoic acid attenuates dexamethasome-induced apoptosis by inducing adaptive autophagy via GPR120 in murine bone marrow-derived mesenchymal stem cells
por: Gao, B, et al.
Publicado: (2016)

β-Arrestins promote podocyte injury by inhibition of autophagy in diabetic nephropathy
por: Liu, J, et al.
Publicado: (2016)

Inhibition of apoptosis through AKT-mTOR pathway in ovarian cancer and renal cancer
por: Chen, Hongrun, et al.
Publicado: (2023)

Asymmetric dimethylarginine attenuates serum starvation-induced apoptosis via suppression of the Fas (APO-1/CD95)/JNK (SAPK) pathway
por: Li, H, et al.
Publicado: (2013)

Actein induces autophagy and apoptosis in human bladder cancer by potentiating ROS/JNK and inhibiting AKT pathways
por: Ji, Lu, et al.
Publicado: (2017)

Ursolic acid-mediated changes in glycolytic pathway promote cytotoxic autophagy and apoptosis in phenotypically different breast cancer cells
por: Lewinska, Anna, et al.
Publicado: (2017)

Myricetin induces apoptosis and autophagy in human gastric cancer cells through inhibition of the PI3K/Akt/mTOR pathway
por: Han, So-Hee, et al.
Publicado: (2022)

Cdc42 deficiency induces podocyte apoptosis by inhibiting the Nwasp/stress fibers/YAP pathway
por: Huang, Z, et al.
Publicado: (2016)

Apatinib-induced protective autophagy and apoptosis through the AKT–mTOR pathway in anaplastic thyroid cancer
por: Feng, Haoran, et al.
Publicado: (2018)

Naringin attenuates rat myocardial ischemia/reperfusion injury via PI3K/Akt pathway-mediated inhibition of apoptosis, oxidative stress and autophagy
por: Li, Fengwei, et al.
Publicado: (2021)

Exosomes promote cetuximab resistance via the PTEN/Akt pathway in colon cancer cells
por: Zhang, S., et al.
Publicado: (2017)

Complement C5a exacerbates acute lung injury induced through autophagy-mediated alveolar macrophage apoptosis
por: Hu, R, et al.
Publicado: (2014)

Peroxisome proliferator-activated receptor α activation attenuates the inflammatory response to protect the liver from acute failure by promoting the autophagy pathway
por: Jiao, M, et al.
Publicado: (2014)

Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy
por: Shi, W-Y, et al.
Publicado: (2012)

Notoginsenoside R1 attenuates glucose-induced podocyte injury via the inhibition of apoptosis and the activation of autophagy through the PI3K/Akt/mTOR signaling pathway
por: Huang, Guodong, et al.
Publicado: (2017)

Phosphorylated AKT inhibits the apoptosis induced by DRAM-mediated mitophagy in hepatocellular carcinoma by preventing the translocation of DRAM to mitochondria
por: Liu, K, et al.
Publicado: (2014)

Ischemia preconditioning is neuroprotective in a rat cerebral ischemic injury model through autophagy activation and apoptosis inhibition
por: Xia, D.Y., et al.
Publicado: (2013)

IL10 inhibits starvation-induced autophagy in hypertrophic scar fibroblasts via cross talk between the IL10-IL10R-STAT3 and IL10-AKT-mTOR pathways
por: Shi, J, et al.
Publicado: (2016)

Inhibition of Akt sensitises neuroblastoma cells to gold(III) porphyrin 1a, a novel antitumour drug induced apoptosis and growth inhibition
por: Li, W, et al.
Publicado: (2009)

AKT-GSK3β Signaling Pathway Regulates Mitochondrial Dysfunction-Associated OPA1 Cleavage Contributing to Osteoblast Apoptosis: Preventative Effects of Hydroxytyrosol
por: Cai, W. J., et al.
Publicado: (2019)

Inhibition of ATG12-mediated autophagy by miR-214 enhances radiosensitivity in colorectal cancer
por: Hu, J. L., et al.
Publicado: (2018)

Biofunctional magnesium-coated Ti6Al4V scaffolds promote autophagy-dependent apoptosis in osteosarcoma by activating the AMPK/mTOR/ULK1 signaling pathway
por: Wei, X., et al.
Publicado: (2021)

Electroacupuncture Inhibits Neuronal Autophagy and Apoptosis via the PI3K/AKT Pathway Following Ischemic Stroke
por: Wang, Man-Man, et al.
Publicado: (2020)

Stigmasterol Simultaneously Induces Apoptosis and Protective Autophagy by Inhibiting Akt/mTOR Pathway in Gastric Cancer Cells
por: Zhao, Huange, et al.
Publicado: (2021)

Genistein sensitizes sarcoma cells in vitro and in vivo by enhancing apoptosis and by inhibiting DSB repair pathways
por: Liu, X.X., et al.
Publicado: (2016)

Schisandrin B attenuates the inflammatory response, oxidative stress and apoptosis induced by traumatic spinal cord injury via inhibition of p53 signaling in adult rats
por: Xin, D.Q., et al.
Publicado: (2017)

Knockdown of VEGFR2 Inhibits Proliferation and Induces Apoptosis in Hemangioma-Derived Endothelial Cells
por: Ou, J.M., et al.
Publicado: (2014)

Inhibition of CCR2 attenuates neuroinflammation and neuronal apoptosis after subarachnoid hemorrhage through the PI3K/Akt pathway
por: Tian, Qi, et al.
Publicado: (2022)

Rescue of myogenic defects in Rb-deficient cells by inhibition of autophagy or by hypoxia-induced glycolytic shift
por: Ciavarra, Giovanni, et al.
Publicado: (2010)

Neoalbaconol induces energy depletion and multiple cell death in cancer cells by targeting PDK1-PI3-K/Akt signaling pathway
por: Deng, Q, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_00vsststb1t3lma3h413st41u5