Inadequate fine-tuning of protein synthesis and failure of amino acid homeostasis following inhibition of the ATPase VCP/p97

The cellular mechanisms that control protein degradation may constitute a non-oncogenic cancer cell vulnerability and, therefore, a therapeutic target. Although this proposition is supported by the clinical success of proteasome inhibitors in some malignancies, most cancers are resistant to proteaso...

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Detalles Bibliográficos
Autores principales: Parzych, K, Chinn, T M, Chen, Z, Loaiza, S, Porsch, F, Valbuena, G N, Kleijnen, M F, Karadimitris, A, Gentleman, E, Keun, H C, Auner, H W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720905/
https://www.ncbi.nlm.nih.gov/pubmed/26720340
http://dx.doi.org/10.1038/cddis.2015.373

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