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A case of Trientine Overdose

Wilson disease is a rare genetic hepatic and neurological disorder of copper accumulation. Trientine is usually used as a second line in the management of patients with this condition. We present a case of a large overdose of Trientine (60 g) resulting in self-limiting dizziness and vomiting with no...

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Autores principales: Hashim, Ahmed, Parnell, Nick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721165/
https://www.ncbi.nlm.nih.gov/pubmed/26862278
http://dx.doi.org/10.4103/0971-6580.172262
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author Hashim, Ahmed
Parnell, Nick
author_facet Hashim, Ahmed
Parnell, Nick
author_sort Hashim, Ahmed
collection PubMed
description Wilson disease is a rare genetic hepatic and neurological disorder of copper accumulation. Trientine is usually used as a second line in the management of patients with this condition. We present a case of a large overdose of Trientine (60 g) resulting in self-limiting dizziness and vomiting with no further clinical sequelae or significant biochemical abnormalities. This case shows that Trientine has a good safety profile and hence could be used as a first line treatment in patients with Wilson's disease who suffer from psychiatric complications and who might be at risk of self-harm.
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spelling pubmed-47211652016-02-09 A case of Trientine Overdose Hashim, Ahmed Parnell, Nick Toxicol Int Case Report Wilson disease is a rare genetic hepatic and neurological disorder of copper accumulation. Trientine is usually used as a second line in the management of patients with this condition. We present a case of a large overdose of Trientine (60 g) resulting in self-limiting dizziness and vomiting with no further clinical sequelae or significant biochemical abnormalities. This case shows that Trientine has a good safety profile and hence could be used as a first line treatment in patients with Wilson's disease who suffer from psychiatric complications and who might be at risk of self-harm. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4721165/ /pubmed/26862278 http://dx.doi.org/10.4103/0971-6580.172262 Text en Copyright: © Toxicology International http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution NonCommercial ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Hashim, Ahmed
Parnell, Nick
A case of Trientine Overdose
title A case of Trientine Overdose
title_full A case of Trientine Overdose
title_fullStr A case of Trientine Overdose
title_full_unstemmed A case of Trientine Overdose
title_short A case of Trientine Overdose
title_sort case of trientine overdose
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721165/
https://www.ncbi.nlm.nih.gov/pubmed/26862278
http://dx.doi.org/10.4103/0971-6580.172262
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