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Primary diffuse large B cell lymphoma arising from a leiomyoma of the uterine corpus
BACKGROUND: Primary diffuse large B cell lymphoma (DLBCL) of the uterus is rare, and primary DLBCL arising from a uterine leiomyoma (collision tumor) has not been reported in the literature. CASE PRESENTATION: We describe the clinical, histological, immunohistochemical, and molecular features of pri...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721194/ https://www.ncbi.nlm.nih.gov/pubmed/26791260 http://dx.doi.org/10.1186/s13000-016-0464-8 |
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author | Zhao, Lianhua Ma, Qiang Wang, Qiushi Zeng, Ying Luo, Qingya Xiao, Hualiang |
author_facet | Zhao, Lianhua Ma, Qiang Wang, Qiushi Zeng, Ying Luo, Qingya Xiao, Hualiang |
author_sort | Zhao, Lianhua |
collection | PubMed |
description | BACKGROUND: Primary diffuse large B cell lymphoma (DLBCL) of the uterus is rare, and primary DLBCL arising from a uterine leiomyoma (collision tumor) has not been reported in the literature. CASE PRESENTATION: We describe the clinical, histological, immunohistochemical, and molecular features of primary DLBCL arising from a leiomyoma in the uterine corpus. A 73-year-old female patient had a uterine mass for 23 years. An ultrasound scan revealed marked enlargement of the uterus, measuring 18.2 × 13 × 16.3 cm, with a 17.6 × 10.9 × 11.6 cm hypoechoic mass in the uterine corpus. The tumors consisted of medium- to large-sized cells exhibiting a diffuse pattern of growth with a well-circumscribed leiomyoma. The neoplastic cells strongly expressed CD79α, CD20 and PAX5. Molecular analyses indicated clonal B-cell receptor gene rearrangement. CONCLUSIONS: To the best of our knowledge, no previous cases of primary DLBCL arising from a leiomyoma have been reported. It is necessary to differentiate a diagnosis of primary DLBCL arising from a leiomyoma from that of leiomyoma with florid reactive lymphocytic infiltration (lymphoma-like lesion). Careful analysis of clinical, histological, immunophenotypic, and genetic features is required to establish the correct diagnosis. |
format | Online Article Text |
id | pubmed-4721194 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-47211942016-01-22 Primary diffuse large B cell lymphoma arising from a leiomyoma of the uterine corpus Zhao, Lianhua Ma, Qiang Wang, Qiushi Zeng, Ying Luo, Qingya Xiao, Hualiang Diagn Pathol Case Report BACKGROUND: Primary diffuse large B cell lymphoma (DLBCL) of the uterus is rare, and primary DLBCL arising from a uterine leiomyoma (collision tumor) has not been reported in the literature. CASE PRESENTATION: We describe the clinical, histological, immunohistochemical, and molecular features of primary DLBCL arising from a leiomyoma in the uterine corpus. A 73-year-old female patient had a uterine mass for 23 years. An ultrasound scan revealed marked enlargement of the uterus, measuring 18.2 × 13 × 16.3 cm, with a 17.6 × 10.9 × 11.6 cm hypoechoic mass in the uterine corpus. The tumors consisted of medium- to large-sized cells exhibiting a diffuse pattern of growth with a well-circumscribed leiomyoma. The neoplastic cells strongly expressed CD79α, CD20 and PAX5. Molecular analyses indicated clonal B-cell receptor gene rearrangement. CONCLUSIONS: To the best of our knowledge, no previous cases of primary DLBCL arising from a leiomyoma have been reported. It is necessary to differentiate a diagnosis of primary DLBCL arising from a leiomyoma from that of leiomyoma with florid reactive lymphocytic infiltration (lymphoma-like lesion). Careful analysis of clinical, histological, immunophenotypic, and genetic features is required to establish the correct diagnosis. BioMed Central 2016-01-20 /pmc/articles/PMC4721194/ /pubmed/26791260 http://dx.doi.org/10.1186/s13000-016-0464-8 Text en © Zhao et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Case Report Zhao, Lianhua Ma, Qiang Wang, Qiushi Zeng, Ying Luo, Qingya Xiao, Hualiang Primary diffuse large B cell lymphoma arising from a leiomyoma of the uterine corpus |
title | Primary diffuse large B cell lymphoma arising from a leiomyoma of the uterine corpus |
title_full | Primary diffuse large B cell lymphoma arising from a leiomyoma of the uterine corpus |
title_fullStr | Primary diffuse large B cell lymphoma arising from a leiomyoma of the uterine corpus |
title_full_unstemmed | Primary diffuse large B cell lymphoma arising from a leiomyoma of the uterine corpus |
title_short | Primary diffuse large B cell lymphoma arising from a leiomyoma of the uterine corpus |
title_sort | primary diffuse large b cell lymphoma arising from a leiomyoma of the uterine corpus |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721194/ https://www.ncbi.nlm.nih.gov/pubmed/26791260 http://dx.doi.org/10.1186/s13000-016-0464-8 |
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