Ultrasensitive Detection of Testosterone Using Microring Resonator with Molecularly Imprinted Polymers

We report ultrasensitive and highly selective detection of testosterone based on microring resonance sensor using molecularly imprinted polymers (MIP). A silicon-on-insulator (SOI) micoring resonator was modified by MIP films (MIPs) on a surface. The MIPs was synthesized by thermopolymerization usin...

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Detalles Bibliográficos
Autores principales: Chen, Yangqing, Liu, Yong, Shen, Xiaodan, Chang, Zhimin, Tang, Longhua, Dong, Wen-Fei, Li, Mingyu, He, Jian-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721797/
https://www.ncbi.nlm.nih.gov/pubmed/26694390
http://dx.doi.org/10.3390/s151229877
Descripción
Sumario:We report ultrasensitive and highly selective detection of testosterone based on microring resonance sensor using molecularly imprinted polymers (MIP). A silicon-on-insulator (SOI) micoring resonator was modified by MIP films (MIPs) on a surface. The MIPs was synthesized by thermopolymerization using methacrylic acid as functional monomer and ethylene glycol dimethacrylate as crosslinking agent. The concentration of detected testosterone varies from 0.05 ng/mL to 10 ng/mL. The detection limit reaches 48.7 pg/mL. Ultrahigh sensitivity, good specificity and reproducibility have been demonstrated, indicating the great potential of making a cost effective and easy to operate lab-on-Chip and down scaling micro-fluidics devices in biosensing.

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