Ultrasensitive Detection of Testosterone Using Microring Resonator with Molecularly Imprinted Polymers

We report ultrasensitive and highly selective detection of testosterone based on microring resonance sensor using molecularly imprinted polymers (MIP). A silicon-on-insulator (SOI) micoring resonator was modified by MIP films (MIPs) on a surface. The MIPs was synthesized by thermopolymerization usin...

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Detalles Bibliográficos
Autores principales: Chen, Yangqing, Liu, Yong, Shen, Xiaodan, Chang, Zhimin, Tang, Longhua, Dong, Wen-Fei, Li, Mingyu, He, Jian-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721797/
https://www.ncbi.nlm.nih.gov/pubmed/26694390
http://dx.doi.org/10.3390/s151229877
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author Chen, Yangqing
Liu, Yong
Shen, Xiaodan
Chang, Zhimin
Tang, Longhua
Dong, Wen-Fei
Li, Mingyu
He, Jian-Jun
author_facet Chen, Yangqing
Liu, Yong
Shen, Xiaodan
Chang, Zhimin
Tang, Longhua
Dong, Wen-Fei
Li, Mingyu
He, Jian-Jun
author_sort Chen, Yangqing
collection PubMed
description We report ultrasensitive and highly selective detection of testosterone based on microring resonance sensor using molecularly imprinted polymers (MIP). A silicon-on-insulator (SOI) micoring resonator was modified by MIP films (MIPs) on a surface. The MIPs was synthesized by thermopolymerization using methacrylic acid as functional monomer and ethylene glycol dimethacrylate as crosslinking agent. The concentration of detected testosterone varies from 0.05 ng/mL to 10 ng/mL. The detection limit reaches 48.7 pg/mL. Ultrahigh sensitivity, good specificity and reproducibility have been demonstrated, indicating the great potential of making a cost effective and easy to operate lab-on-Chip and down scaling micro-fluidics devices in biosensing.
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spelling pubmed-47217972016-01-26 Ultrasensitive Detection of Testosterone Using Microring Resonator with Molecularly Imprinted Polymers Chen, Yangqing Liu, Yong Shen, Xiaodan Chang, Zhimin Tang, Longhua Dong, Wen-Fei Li, Mingyu He, Jian-Jun Sensors (Basel) Article We report ultrasensitive and highly selective detection of testosterone based on microring resonance sensor using molecularly imprinted polymers (MIP). A silicon-on-insulator (SOI) micoring resonator was modified by MIP films (MIPs) on a surface. The MIPs was synthesized by thermopolymerization using methacrylic acid as functional monomer and ethylene glycol dimethacrylate as crosslinking agent. The concentration of detected testosterone varies from 0.05 ng/mL to 10 ng/mL. The detection limit reaches 48.7 pg/mL. Ultrahigh sensitivity, good specificity and reproducibility have been demonstrated, indicating the great potential of making a cost effective and easy to operate lab-on-Chip and down scaling micro-fluidics devices in biosensing. MDPI 2015-12-15 /pmc/articles/PMC4721797/ /pubmed/26694390 http://dx.doi.org/10.3390/s151229877 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Yangqing
Liu, Yong
Shen, Xiaodan
Chang, Zhimin
Tang, Longhua
Dong, Wen-Fei
Li, Mingyu
He, Jian-Jun
Ultrasensitive Detection of Testosterone Using Microring Resonator with Molecularly Imprinted Polymers
title Ultrasensitive Detection of Testosterone Using Microring Resonator with Molecularly Imprinted Polymers
title_full Ultrasensitive Detection of Testosterone Using Microring Resonator with Molecularly Imprinted Polymers
title_fullStr Ultrasensitive Detection of Testosterone Using Microring Resonator with Molecularly Imprinted Polymers
title_full_unstemmed Ultrasensitive Detection of Testosterone Using Microring Resonator with Molecularly Imprinted Polymers
title_short Ultrasensitive Detection of Testosterone Using Microring Resonator with Molecularly Imprinted Polymers
title_sort ultrasensitive detection of testosterone using microring resonator with molecularly imprinted polymers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721797/
https://www.ncbi.nlm.nih.gov/pubmed/26694390
http://dx.doi.org/10.3390/s151229877
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