Synthesis and Sensing Applications of Fluorescent 3-Cinnamoyl Coumarins

We have synthesized two novel fluorescent 3-(4-diethylaminocinnamoyl) coumarins that exhibit fluorescence quenching upon exposure to a nerve agent simulant, diethylchlorophosphate (DCP), providing a basis for rapid and sensitive DCP chemosensing. Furthermore, these coumarin derivatives display two-p...

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Autores principales: Yadav, Preeti, Gill, Hardeep Singh, Chand, Karam, Li, Lian, Kumar, Jayant, Sharma, Sunil K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721820/
https://www.ncbi.nlm.nih.gov/pubmed/26703600
http://dx.doi.org/10.3390/s151229902
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author Yadav, Preeti
Gill, Hardeep Singh
Chand, Karam
Li, Lian
Kumar, Jayant
Sharma, Sunil K.
author_facet Yadav, Preeti
Gill, Hardeep Singh
Chand, Karam
Li, Lian
Kumar, Jayant
Sharma, Sunil K.
author_sort Yadav, Preeti
collection PubMed
description We have synthesized two novel fluorescent 3-(4-diethylaminocinnamoyl) coumarins that exhibit fluorescence quenching upon exposure to a nerve agent simulant, diethylchlorophosphate (DCP), providing a basis for rapid and sensitive DCP chemosensing. Furthermore, these coumarin derivatives display two-photon fluorescence upon illumination with near-infrared laser pulses and their two-photon (TP) absorption cross-section was evaluated. The potential for TP bio-imaging of these compounds was investigated by their cellular uptake in HeLa cells by TP confocal microscopy.
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spelling pubmed-47218202016-01-26 Synthesis and Sensing Applications of Fluorescent 3-Cinnamoyl Coumarins Yadav, Preeti Gill, Hardeep Singh Chand, Karam Li, Lian Kumar, Jayant Sharma, Sunil K. Sensors (Basel) Article We have synthesized two novel fluorescent 3-(4-diethylaminocinnamoyl) coumarins that exhibit fluorescence quenching upon exposure to a nerve agent simulant, diethylchlorophosphate (DCP), providing a basis for rapid and sensitive DCP chemosensing. Furthermore, these coumarin derivatives display two-photon fluorescence upon illumination with near-infrared laser pulses and their two-photon (TP) absorption cross-section was evaluated. The potential for TP bio-imaging of these compounds was investigated by their cellular uptake in HeLa cells by TP confocal microscopy. MDPI 2015-12-19 /pmc/articles/PMC4721820/ /pubmed/26703600 http://dx.doi.org/10.3390/s151229902 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yadav, Preeti
Gill, Hardeep Singh
Chand, Karam
Li, Lian
Kumar, Jayant
Sharma, Sunil K.
Synthesis and Sensing Applications of Fluorescent 3-Cinnamoyl Coumarins
title Synthesis and Sensing Applications of Fluorescent 3-Cinnamoyl Coumarins
title_full Synthesis and Sensing Applications of Fluorescent 3-Cinnamoyl Coumarins
title_fullStr Synthesis and Sensing Applications of Fluorescent 3-Cinnamoyl Coumarins
title_full_unstemmed Synthesis and Sensing Applications of Fluorescent 3-Cinnamoyl Coumarins
title_short Synthesis and Sensing Applications of Fluorescent 3-Cinnamoyl Coumarins
title_sort synthesis and sensing applications of fluorescent 3-cinnamoyl coumarins
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721820/
https://www.ncbi.nlm.nih.gov/pubmed/26703600
http://dx.doi.org/10.3390/s151229902
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