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An Algorithm to Automatically Generate the Combinatorial Orbit Counting Equations
Graphlets are small subgraphs, usually containing up to five vertices, that can be found in a larger graph. Identification of the graphlets that a vertex in an explored graph touches can provide useful information about the local structure of the graph around that vertex. Actually finding all graphl...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721873/ https://www.ncbi.nlm.nih.gov/pubmed/26797021 http://dx.doi.org/10.1371/journal.pone.0147078 |
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author | Melckenbeeck, Ine Audenaert, Pieter Michoel, Tom Colle, Didier Pickavet, Mario |
author_facet | Melckenbeeck, Ine Audenaert, Pieter Michoel, Tom Colle, Didier Pickavet, Mario |
author_sort | Melckenbeeck, Ine |
collection | PubMed |
description | Graphlets are small subgraphs, usually containing up to five vertices, that can be found in a larger graph. Identification of the graphlets that a vertex in an explored graph touches can provide useful information about the local structure of the graph around that vertex. Actually finding all graphlets in a large graph can be time-consuming, however. As the graphlets grow in size, more different graphlets emerge and the time needed to find each graphlet also scales up. If it is not needed to find each instance of each graphlet, but knowing the number of graphlets touching each node of the graph suffices, the problem is less hard. Previous research shows a way to simplify counting the graphlets: instead of looking for the graphlets needed, smaller graphlets are searched, as well as the number of common neighbors of vertices. Solving a system of equations then gives the number of times a vertex is part of each graphlet of the desired size. However, until now, equations only exist to count graphlets with 4 or 5 nodes. In this paper, two new techniques are presented. The first allows to generate the equations needed in an automatic way. This eliminates the tedious work needed to do so manually each time an extra node is added to the graphlets. The technique is independent on the number of nodes in the graphlets and can thus be used to count larger graphlets than previously possible. The second technique gives all graphlets a unique ordering which is easily extended to name graphlets of any size. Both techniques were used to generate equations to count graphlets with 4, 5 and 6 vertices, which extends all previous results. Code can be found at https://github.com/IneMelckenbeeck/equation-generator and https://github.com/IneMelckenbeeck/graphlet-naming. |
format | Online Article Text |
id | pubmed-4721873 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-47218732016-01-30 An Algorithm to Automatically Generate the Combinatorial Orbit Counting Equations Melckenbeeck, Ine Audenaert, Pieter Michoel, Tom Colle, Didier Pickavet, Mario PLoS One Research Article Graphlets are small subgraphs, usually containing up to five vertices, that can be found in a larger graph. Identification of the graphlets that a vertex in an explored graph touches can provide useful information about the local structure of the graph around that vertex. Actually finding all graphlets in a large graph can be time-consuming, however. As the graphlets grow in size, more different graphlets emerge and the time needed to find each graphlet also scales up. If it is not needed to find each instance of each graphlet, but knowing the number of graphlets touching each node of the graph suffices, the problem is less hard. Previous research shows a way to simplify counting the graphlets: instead of looking for the graphlets needed, smaller graphlets are searched, as well as the number of common neighbors of vertices. Solving a system of equations then gives the number of times a vertex is part of each graphlet of the desired size. However, until now, equations only exist to count graphlets with 4 or 5 nodes. In this paper, two new techniques are presented. The first allows to generate the equations needed in an automatic way. This eliminates the tedious work needed to do so manually each time an extra node is added to the graphlets. The technique is independent on the number of nodes in the graphlets and can thus be used to count larger graphlets than previously possible. The second technique gives all graphlets a unique ordering which is easily extended to name graphlets of any size. Both techniques were used to generate equations to count graphlets with 4, 5 and 6 vertices, which extends all previous results. Code can be found at https://github.com/IneMelckenbeeck/equation-generator and https://github.com/IneMelckenbeeck/graphlet-naming. Public Library of Science 2016-01-21 /pmc/articles/PMC4721873/ /pubmed/26797021 http://dx.doi.org/10.1371/journal.pone.0147078 Text en © 2016 Melckenbeeck et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Melckenbeeck, Ine Audenaert, Pieter Michoel, Tom Colle, Didier Pickavet, Mario An Algorithm to Automatically Generate the Combinatorial Orbit Counting Equations |
title | An Algorithm to Automatically Generate the Combinatorial Orbit Counting Equations |
title_full | An Algorithm to Automatically Generate the Combinatorial Orbit Counting Equations |
title_fullStr | An Algorithm to Automatically Generate the Combinatorial Orbit Counting Equations |
title_full_unstemmed | An Algorithm to Automatically Generate the Combinatorial Orbit Counting Equations |
title_short | An Algorithm to Automatically Generate the Combinatorial Orbit Counting Equations |
title_sort | algorithm to automatically generate the combinatorial orbit counting equations |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721873/ https://www.ncbi.nlm.nih.gov/pubmed/26797021 http://dx.doi.org/10.1371/journal.pone.0147078 |
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