The Role of Immune Cells in Chronic HBV Infection

Hepatitis B virus (HBV) infection is a major cause of chronic liver diseases that may progress to liver cirrhosis and hepatocellular carcinoma. Host immune responses are important factors that determine whether HBV infection is cleared or persists. After infection, viral replication occurs inside he...

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Detalles Bibliográficos
Autores principales: Li, Hai-Jun, Zhai, Nai-Cui, Song, Hong-Xiao, Yang, Yang, Cui, An, Li, Tian-Yang, Tu, Zheng-Kun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: XIA & HE Publishing Ltd 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721896/
https://www.ncbi.nlm.nih.gov/pubmed/26807384
http://dx.doi.org/10.14218/JCTH.2015.00026
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author Li, Hai-Jun
Zhai, Nai-Cui
Song, Hong-Xiao
Yang, Yang
Cui, An
Li, Tian-Yang
Tu, Zheng-Kun
author_facet Li, Hai-Jun
Zhai, Nai-Cui
Song, Hong-Xiao
Yang, Yang
Cui, An
Li, Tian-Yang
Tu, Zheng-Kun
author_sort Li, Hai-Jun
collection PubMed
description Hepatitis B virus (HBV) infection is a major cause of chronic liver diseases that may progress to liver cirrhosis and hepatocellular carcinoma. Host immune responses are important factors that determine whether HBV infection is cleared or persists. After infection, viral replication occurs inside hepatocytes, and the secretion of infectious virions can take place at high rates for decades. Consequently, HBV DNA and viral proteins, like HBV early antigen (HBeAg) and HBV surface antigen (HBsAg), can be easily detected in serum. Chronic infection with HBV is the result of an ineffective antiviral immune response towards the virus. In this review, we discuss the role of immune cells in chronic HBV infection.
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spelling pubmed-47218962016-01-22 The Role of Immune Cells in Chronic HBV Infection Li, Hai-Jun Zhai, Nai-Cui Song, Hong-Xiao Yang, Yang Cui, An Li, Tian-Yang Tu, Zheng-Kun J Clin Transl Hepatol Review Article Hepatitis B virus (HBV) infection is a major cause of chronic liver diseases that may progress to liver cirrhosis and hepatocellular carcinoma. Host immune responses are important factors that determine whether HBV infection is cleared or persists. After infection, viral replication occurs inside hepatocytes, and the secretion of infectious virions can take place at high rates for decades. Consequently, HBV DNA and viral proteins, like HBV early antigen (HBeAg) and HBV surface antigen (HBsAg), can be easily detected in serum. Chronic infection with HBV is the result of an ineffective antiviral immune response towards the virus. In this review, we discuss the role of immune cells in chronic HBV infection. XIA & HE Publishing Ltd 2015-12-15 2015-12-28 /pmc/articles/PMC4721896/ /pubmed/26807384 http://dx.doi.org/10.14218/JCTH.2015.00026 Text en © 2015 The Second Affiliated Hospital of Chongqing Medical University. Published by XIA & HE Publishing Ltd. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 4.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Li, Hai-Jun
Zhai, Nai-Cui
Song, Hong-Xiao
Yang, Yang
Cui, An
Li, Tian-Yang
Tu, Zheng-Kun
The Role of Immune Cells in Chronic HBV Infection
title The Role of Immune Cells in Chronic HBV Infection
title_full The Role of Immune Cells in Chronic HBV Infection
title_fullStr The Role of Immune Cells in Chronic HBV Infection
title_full_unstemmed The Role of Immune Cells in Chronic HBV Infection
title_short The Role of Immune Cells in Chronic HBV Infection
title_sort role of immune cells in chronic hbv infection
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721896/
https://www.ncbi.nlm.nih.gov/pubmed/26807384
http://dx.doi.org/10.14218/JCTH.2015.00026
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