Cargando…

Effects of Combined CCR5/Integrase Inhibitors-Based Regimen on Mucosal Immunity in HIV-Infected Patients Naïve to Antiretroviral Therapy: A Pilot Randomized Trial

Whether initiation of antiretroviral therapy (ART) regimens aimed at achieving greater concentrations within gut associated lymphoid tissue (GALT) impacts the level of mucosal immune reconstitution, inflammatory markers and the viral reservoir remains unknown. We included 12 HIV- controls and 32 ART...

Descripción completa

Detalles Bibliográficos
Autores principales:	Serrano-Villar, Sergio, Sainz, Talia, Ma, Zhong-Min, Utay, Netanya S., Wook-Chun, Tae, Mann, Surinder, Kashuba, Angela D., Siewe, Basile, Albanese, Anthony, Troia-Cancio, Paolo, Sinclair, Elizabeth, Somasunderam, Anoma, Yotter, Tammy, Deeks, Steven G., Landay, Alan, Pollard, Richard B., Miller, Christopher J., Moreno, Santiago, Asmuth, David M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721954/ https://www.ncbi.nlm.nih.gov/pubmed/26795282 http://dx.doi.org/10.1371/journal.ppat.1005381

Ejemplares similares

Correction: Effects of Combined CCR5/Integrase Inhibitors-Based Regimen on Mucosal Immunity in HIV-Infected Patients Naïve to Antiretroviral Therapy: A Pilot Randomized Trial
por: Serrano-Villar, Sergio, et al.
Publicado: (2016)

Correction: Effects of Combined CCR5/Integrase Inhibitors-Based Regimen on Mucosal Immunity in HIV-Infected Patients Naïve to Antiretroviral Therapy: A Pilot Randomized Trial
por: Serrano-Villar, Sergio, et al.
Publicado: (2017)

Adiponectin and the steatosis marker Chi3L1 decrease following switch to raltegravir compared to continued PI/NNRTI-based antiretroviral therapy
por: Offor, Obiageli, et al.
Publicado: (2018)

Serum Bovine Immunoglobulins Improve Inflammation and Gut Barrier Function in Persons with HIV and Enteropathy on Suppressive ART
por: Utay, Netanya S., et al.
Publicado: (2019)

376. Effect of Parasitic Infections on Gut Epithelial Barrier and Immune Activation among Foreign-Born HIV-infected Patients
por: Reimer-McAtee, Melissa, et al.
Publicado: (2019)

Pharmacokinetics, Safety, and CCR2/CCR5 Antagonist Activity of Cenicriviroc in Participants With Mild or Moderate Hepatic Impairment
por: Lefebvre, E, et al.
Publicado: (2016)

Fibrogenic Gene Expression in Hepatic Stellate Cells Induced by HCV and HIV Replication in a Three Cell Co-Culture Model System
por: Akil, Abdellah, et al.
Publicado: (2019)

Circulating LOXL2 Levels Reflect Severity of Intestinal Fibrosis and GALT CD4(+) T Lymphocyte Depletion in Treated HIV Infection
por: Seang, Sophie, et al.
Publicado: (2017)

2517. Oral Fecal Microbiota Transplantation Increases Gut Microbiome Diversity and Alters the Microbiome Distribution in People with HIV
por: Utay, Netanya S, et al.
Publicado: (2019)

Potential use of serum‐derived bovine immunoglobulin/protein isolate for the management of COVID‐19
por: Utay, Netanya S., et al.
Publicado: (2021)

Oral serum-derived bovine immunoglobulin improves duodenal immune reconstitution and absorption function in patients with HIV enteropathy
por: Asmuth, David M., et al.
Publicado: (2013)

MRSA Infections in HIV-Infected People Are Associated with Decreased MRSA-Specific Th1 Immunity
por: Utay, Netanya S., et al.
Publicado: (2016)

Evaluation of Six Weekly Oral Fecal Microbiota Transplants in People with HIV
por: Utay, Netanya S., et al.
Publicado: (2020)

Interferons and HIV Infection: The Good, the Bad, and the Ugly
por: Utay, Netanya S., et al.
Publicado: (2016)

Hepatic steatosis in HCV-infected persons in the direct-acting antiviral era
por: Stevenson, Heather L., et al.
Publicado: (2016)

Regulatory B Cells Inhibit Cytotoxic T Lymphocyte (CTL) Activity and Elimination of Infected CD4 T Cells after In Vitro Reactivation of HIV Latent Reservoirs
por: Siewe, Basile, et al.
Publicado: (2014)

1048. Weight Gain after Initiation of Anti-Retroviral Therapy in Acute HIV-1
por: Kaur, Harmanpreet, et al.
Publicado: (2020)

FcRL4 Expression Identifies a Pro-inflammatory B Cell Subset in Viremic HIV-Infected Subjects
por: Siewe, Basile, et al.
Publicado: (2017)

Stability of plasma indices of inflammation/coagulation and homeostasis after fatty and non-fatty meals in treated people with HIV
por: Dorazio, Dominic, et al.
Publicado: (2019)

Integrase and integration: biochemical activities of HIV-1 integrase
por: Delelis, Olivier, et al.
Publicado: (2008)

Acute HIV infection (AHI): Trained Service Linkage Workers and fourth-generation Assay Significantly Shorten Time to Antiretroviral Therapy Initiation.
por: Smith, Daniel, et al.
Publicado: (2017)

Neurological Response to cART vs. cART plus Integrase Inhibitor and CCR5 Antagonist Initiated during Acute HIV
por: Valcour, Victor G., et al.
Publicado: (2015)

Resistance to Integrase Inhibitors
por: Métifiot, Mathieu, et al.
Publicado: (2010)

Relationship between HIV integrase polymorphisms and integrase inhibitor susceptibility: An in silico analysis
por: Hutapea, Hotma Martogi Lorensi, et al.
Publicado: (2018)

GCN5-dependent acetylation of HIV-1 integrase enhances viral integration
por: Terreni, Mariaelena, et al.
Publicado: (2009)

GCN5-dependent acetylation of HIV-1 integrase enhances viral integration
por: Terreni, Mariaelena, et al.
Publicado: (2010)

HIV-2 Integrase Variation in Integrase Inhibitor-Naïve Adults in Senegal, West Africa
por: Gottlieb, Geoffrey S., et al.
Publicado: (2011)

HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors
por: Koneru, Pratibha C, et al.
Publicado: (2019)

Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis
por: Elliott, Jennifer L, et al.
Publicado: (2020)

Prototype Foamy Virus Integrase Displays Unique Biochemical Activities among Retroviral Integrases
por: Rabe, Anthony J., et al.
Publicado: (2021)

The dual role of tetraspanin CD63 in HIV-1 replication
por: Li, Guangyu, et al.
Publicado: (2014)

Upregulation of the Chemokine Receptor CCR2B in Epstein‒Barr Virus-Positive Burkitt Lymphoma Cell Lines with the Latency III Program
por: Kozireva, Svetlana, et al.
Publicado: (2018)

Predictive value of CD8+ T cell and CD4/CD8 ratio at two years of successful ART in the risk of AIDS and non-AIDS events
por: Serrano-Villar, Sergio, et al.
Publicado: (2022)

Raised Venous Lactate and Markers of Intestinal Translocation Are Associated With Mortality Among In-Patients With HIV-Associated TB in Rural South Africa
por: Subbarao, Sathyavani, et al.
Publicado: (2015)

Comparison of liver biopsies before and after direct-acting antiviral therapy for hepatitis C and correlation with clinical outcome
por: Saldarriaga, Omar A., et al.
Publicado: (2021)

New Applications for Phage Integrases
por: Fogg, Paul C.M., et al.
Publicado: (2014)

HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases
por: Zhao, Xue Zhi, et al.
Publicado: (2016)

HIV-1 Integrase Inhibitors with Modifications That Affect Their Potencies against Drug Resistant Integrase Mutants
por: Smith, Steven J., et al.
Publicado: (2021)

1336. Presence of Antibodies to non-SARS-CoV-2 Associates With Generation of Neutralizing Antibodies to SARS-CoV-2 Following mRNA Vaccination
por: Al Hammoud, Roukaya, et al.
Publicado: (2023)

A novel function for spumaretrovirus integrase: an early requirement for integrase-mediated cleavage of 2 LTR circles
por: Delelis, Olivier, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_16g284hn5rtcjaijtuj726eesm