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Human papillomavirus infection and risk of lung cancer in never-smokers and women: an ‘adaptive’ meta-analysis
OBJECTIVES: The incidence of lung cancer in Koreans is increasing in women and in both men and women with a never-smoking history. Human papillomavirus (HPV) infection has been suggested as a modifiable risk factor of lung cancer in never-smokers and women (LCNSW). This systematic review (SR) aimed...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Society of Epidemiology
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722221/ https://www.ncbi.nlm.nih.gov/pubmed/26602770 http://dx.doi.org/10.4178/epih/e2015052 |
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author | Bae, Jong-Myon Kim, Eun Hee |
author_facet | Bae, Jong-Myon Kim, Eun Hee |
author_sort | Bae, Jong-Myon |
collection | PubMed |
description | OBJECTIVES: The incidence of lung cancer in Koreans is increasing in women and in both men and women with a never-smoking history. Human papillomavirus (HPV) infection has been suggested as a modifiable risk factor of lung cancer in never-smokers and women (LCNSW). This systematic review (SR) aimed to evaluate an association between HPV infection and lung cancer risk in LCNSW. METHODS: Based on a prior SR and some expert reviews, we identified refereed, cited, or related articles using the PubMed and Scopus databases. All case-control studies that reported the odds ratio of HPV infection in LCNSW were selected. An estimate of the summary odds ratio (SOR) with 95% confidence intervals (CI) was calculated. RESULTS: A total of four case-control studies were included. The fixed-effect model was applied because of homogeneity (I-squared=0.0%). The SORs in women and in never-smokers were 5.32 (95% CI, 1.75 to 16.17) and 4.78 (2.25 to 10.15) respectively. CONCLUSIONS: These results showed a significant effect of HPV infection in LCNSW. It is evident that developing a preventive plan against LCNSW may be necessary. |
format | Online Article Text |
id | pubmed-4722221 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Korean Society of Epidemiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-47222212016-01-27 Human papillomavirus infection and risk of lung cancer in never-smokers and women: an ‘adaptive’ meta-analysis Bae, Jong-Myon Kim, Eun Hee Epidemiol Health Review OBJECTIVES: The incidence of lung cancer in Koreans is increasing in women and in both men and women with a never-smoking history. Human papillomavirus (HPV) infection has been suggested as a modifiable risk factor of lung cancer in never-smokers and women (LCNSW). This systematic review (SR) aimed to evaluate an association between HPV infection and lung cancer risk in LCNSW. METHODS: Based on a prior SR and some expert reviews, we identified refereed, cited, or related articles using the PubMed and Scopus databases. All case-control studies that reported the odds ratio of HPV infection in LCNSW were selected. An estimate of the summary odds ratio (SOR) with 95% confidence intervals (CI) was calculated. RESULTS: A total of four case-control studies were included. The fixed-effect model was applied because of homogeneity (I-squared=0.0%). The SORs in women and in never-smokers were 5.32 (95% CI, 1.75 to 16.17) and 4.78 (2.25 to 10.15) respectively. CONCLUSIONS: These results showed a significant effect of HPV infection in LCNSW. It is evident that developing a preventive plan against LCNSW may be necessary. Korean Society of Epidemiology 2015-11-17 /pmc/articles/PMC4722221/ /pubmed/26602770 http://dx.doi.org/10.4178/epih/e2015052 Text en ©2015, Korean Society of Epidemiology This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Bae, Jong-Myon Kim, Eun Hee Human papillomavirus infection and risk of lung cancer in never-smokers and women: an ‘adaptive’ meta-analysis |
title | Human papillomavirus infection and risk of lung cancer in never-smokers and women: an ‘adaptive’ meta-analysis |
title_full | Human papillomavirus infection and risk of lung cancer in never-smokers and women: an ‘adaptive’ meta-analysis |
title_fullStr | Human papillomavirus infection and risk of lung cancer in never-smokers and women: an ‘adaptive’ meta-analysis |
title_full_unstemmed | Human papillomavirus infection and risk of lung cancer in never-smokers and women: an ‘adaptive’ meta-analysis |
title_short | Human papillomavirus infection and risk of lung cancer in never-smokers and women: an ‘adaptive’ meta-analysis |
title_sort | human papillomavirus infection and risk of lung cancer in never-smokers and women: an ‘adaptive’ meta-analysis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722221/ https://www.ncbi.nlm.nih.gov/pubmed/26602770 http://dx.doi.org/10.4178/epih/e2015052 |
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