Secondary association of PDLIM5 with paranoid schizophrenia in Emirati patients

Schizophrenia is a clinically and genetically heterogeneous disorder of unknown etiology. PDLIM5 variants have been linked to schizophrenia and other related neuropsychiatric disorders and upregulated in the brain of schizophrenia patients suggesting a possible pathogenic role in disease progression...

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Autores principales: Moselhy, Hamdy, Eapen, Valsamma, Akawi, Nadia A., Younis, Ali, Salih, Badr, Othman, Aws R., Yousef, Said, Clarke, Raymond A., Ali, Bassam R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722529/
https://www.ncbi.nlm.nih.gov/pubmed/26925374
http://dx.doi.org/10.1016/j.mgene.2015.07.002
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author Moselhy, Hamdy
Eapen, Valsamma
Akawi, Nadia A.
Younis, Ali
Salih, Badr
Othman, Aws R.
Yousef, Said
Clarke, Raymond A.
Ali, Bassam R.
author_facet Moselhy, Hamdy
Eapen, Valsamma
Akawi, Nadia A.
Younis, Ali
Salih, Badr
Othman, Aws R.
Yousef, Said
Clarke, Raymond A.
Ali, Bassam R.
author_sort Moselhy, Hamdy
collection PubMed
description Schizophrenia is a clinically and genetically heterogeneous disorder of unknown etiology. PDLIM5 variants have been linked to schizophrenia and other related neuropsychiatric disorders and upregulated in the brain of schizophrenia patients suggesting a possible pathogenic role in disease progression. The aim of this study is to examine the potential association of schizophrenia in Emirati patients with previously reported variants in PDLIM5, PICK1, NRG3 or DISC1 genes. Consequently, we found a secondary association between PDLIM5 variants and the paranoid subtype of schizophrenia in Emirati Arabs suggesting that PDLIM5 may represent a determinate/marker for schizophrenia subtype specification. However, no associations were found with variants in PICK1, NRG3 or DISC1 genes.
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spelling pubmed-47225292016-02-26 Secondary association of PDLIM5 with paranoid schizophrenia in Emirati patients Moselhy, Hamdy Eapen, Valsamma Akawi, Nadia A. Younis, Ali Salih, Badr Othman, Aws R. Yousef, Said Clarke, Raymond A. Ali, Bassam R. Meta Gene Article Schizophrenia is a clinically and genetically heterogeneous disorder of unknown etiology. PDLIM5 variants have been linked to schizophrenia and other related neuropsychiatric disorders and upregulated in the brain of schizophrenia patients suggesting a possible pathogenic role in disease progression. The aim of this study is to examine the potential association of schizophrenia in Emirati patients with previously reported variants in PDLIM5, PICK1, NRG3 or DISC1 genes. Consequently, we found a secondary association between PDLIM5 variants and the paranoid subtype of schizophrenia in Emirati Arabs suggesting that PDLIM5 may represent a determinate/marker for schizophrenia subtype specification. However, no associations were found with variants in PICK1, NRG3 or DISC1 genes. Elsevier 2015-07-21 /pmc/articles/PMC4722529/ /pubmed/26925374 http://dx.doi.org/10.1016/j.mgene.2015.07.002 Text en © 2015 The Authors. Published by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Moselhy, Hamdy
Eapen, Valsamma
Akawi, Nadia A.
Younis, Ali
Salih, Badr
Othman, Aws R.
Yousef, Said
Clarke, Raymond A.
Ali, Bassam R.
Secondary association of PDLIM5 with paranoid schizophrenia in Emirati patients
title Secondary association of PDLIM5 with paranoid schizophrenia in Emirati patients
title_full Secondary association of PDLIM5 with paranoid schizophrenia in Emirati patients
title_fullStr Secondary association of PDLIM5 with paranoid schizophrenia in Emirati patients
title_full_unstemmed Secondary association of PDLIM5 with paranoid schizophrenia in Emirati patients
title_short Secondary association of PDLIM5 with paranoid schizophrenia in Emirati patients
title_sort secondary association of pdlim5 with paranoid schizophrenia in emirati patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722529/
https://www.ncbi.nlm.nih.gov/pubmed/26925374
http://dx.doi.org/10.1016/j.mgene.2015.07.002
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