Mechanisms underlying epigenetic and transcriptional heterogeneity in Chinese hamster ovary (CHO) cell lines

BACKGROUND: Recombinant cell lines developed for therapeutic antibody production often suffer instability or lose recombinant protein expression during long-term culture. Heterogeneous gene expression among cell line subclones may result from epigenetic modifications of DNA or histones, the protein...

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Detalles Bibliográficos
Autores principales: Veith, Nathalie, Ziehr, Holger, MacLeod, Roderick A. F., Reamon-Buettner, Stella Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722726/
https://www.ncbi.nlm.nih.gov/pubmed/26800878
http://dx.doi.org/10.1186/s12896-016-0238-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722726/
https://www.ncbi.nlm.nih.gov/pubmed/26800878
http://dx.doi.org/10.1186/s12896-016-0238-0

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