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Mechanisms underlying epigenetic and transcriptional heterogeneity in Chinese hamster ovary (CHO) cell lines

BACKGROUND: Recombinant cell lines developed for therapeutic antibody production often suffer instability or lose recombinant protein expression during long-term culture. Heterogeneous gene expression among cell line subclones may result from epigenetic modifications of DNA or histones, the protein...

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Detalles Bibliográficos
Autores principales:	Veith, Nathalie, Ziehr, Holger, MacLeod, Roderick A. F., Reamon-Buettner, Stella Marie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722726/ https://www.ncbi.nlm.nih.gov/pubmed/26800878 http://dx.doi.org/10.1186/s12896-016-0238-0

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