Heparan sulfate proteoglycans mediate Aβ-induced oxidative stress and hypercontractility in cultured vascular smooth muscle cells

BACKGROUND: Substantial evidence suggests that amyloid-β (Aβ) species induce oxidative stress and cerebrovascular (CV) dysfunction in Alzheimer’s disease (AD), potentially contributing to the progressive dementia of this disease. The upstream molecular pathways governing this process, however, are p...

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Detalles Bibliográficos
Autores principales: Reynolds, Matthew R., Singh, Itender, Azad, Tej D., Holmes, Brandon B., Verghese, Phillip B., Dietrich, Hans H., Diamond, Marc, Bu, Guojun, Han, Byung Hee, Zipfel, Gregory J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722750/
https://www.ncbi.nlm.nih.gov/pubmed/26801396
http://dx.doi.org/10.1186/s13024-016-0073-8

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