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Influence of essential amino acids on muscle mass and muscle strength in patients with cerebral stroke during early rehabilitation: protocol and rationale of a randomized clinical trial (AMINO-Stroke Study)

BACKGROUND: Patients with stroke are at a high risk for long-term handicap and disability. In the first weeks after stroke muscle wasting is observed frequently. Early post-stroke rehabilitation programs are directed to improve functional independence and physical performance. Supplementation with e...

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Autores principales: Scherbakov, Nadja, Ebner, Nicole, Sandek, Anja, Meisel, Andreas, Haeusler, Karl Georg, von Haehling, Stephan, Anker, Stefan D., Dirnagl, Ulrich, Joebges, Michael, Doehner, Wolfram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722757/
https://www.ncbi.nlm.nih.gov/pubmed/26793971
http://dx.doi.org/10.1186/s12883-016-0531-5
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author Scherbakov, Nadja
Ebner, Nicole
Sandek, Anja
Meisel, Andreas
Haeusler, Karl Georg
von Haehling, Stephan
Anker, Stefan D.
Dirnagl, Ulrich
Joebges, Michael
Doehner, Wolfram
author_facet Scherbakov, Nadja
Ebner, Nicole
Sandek, Anja
Meisel, Andreas
Haeusler, Karl Georg
von Haehling, Stephan
Anker, Stefan D.
Dirnagl, Ulrich
Joebges, Michael
Doehner, Wolfram
author_sort Scherbakov, Nadja
collection PubMed
description BACKGROUND: Patients with stroke are at a high risk for long-term handicap and disability. In the first weeks after stroke muscle wasting is observed frequently. Early post-stroke rehabilitation programs are directed to improve functional independence and physical performance. Supplementation with essential amino acids (EAAs) might prevent muscle wasting and improve rehabilitation outcome by augmenting muscle mass and muscle strength. We aim to examine this in a double blinded, randomized placebo-controlled clinical trial. METHODS: Patients with ischemic or haemorrhagic stroke will be enrolled at begin of the early post-stroke rehabilitation in a parallel group interventional trial. Oral supplementation of EAAs or placebo will be given for 12 weeks in a double blinded manner. Physical and functional performance will be assessed by exercise testing before supplementation of EAAs as well as at discharge from the in-patient rehabilitation, at 12 weeks and 1 year afterwards. DISCUSSION: This is the first randomized double-blinded placebo-controlled clinical study aiming to assess the effect of the EAAs supplementation on muscle strength, muscle function and physical performance in stroke patients during early post-stroke rehabilitation. Supplementation of EAAs could prevent muscle mass wasting and improve functional independence after stroke. TRIAL REGISTRATION: The study is registered at the German registry for clinical trials as well as at World Health Organization (WHO; number DRKS00005577).
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spelling pubmed-47227572016-01-23 Influence of essential amino acids on muscle mass and muscle strength in patients with cerebral stroke during early rehabilitation: protocol and rationale of a randomized clinical trial (AMINO-Stroke Study) Scherbakov, Nadja Ebner, Nicole Sandek, Anja Meisel, Andreas Haeusler, Karl Georg von Haehling, Stephan Anker, Stefan D. Dirnagl, Ulrich Joebges, Michael Doehner, Wolfram BMC Neurol Study Protocol BACKGROUND: Patients with stroke are at a high risk for long-term handicap and disability. In the first weeks after stroke muscle wasting is observed frequently. Early post-stroke rehabilitation programs are directed to improve functional independence and physical performance. Supplementation with essential amino acids (EAAs) might prevent muscle wasting and improve rehabilitation outcome by augmenting muscle mass and muscle strength. We aim to examine this in a double blinded, randomized placebo-controlled clinical trial. METHODS: Patients with ischemic or haemorrhagic stroke will be enrolled at begin of the early post-stroke rehabilitation in a parallel group interventional trial. Oral supplementation of EAAs or placebo will be given for 12 weeks in a double blinded manner. Physical and functional performance will be assessed by exercise testing before supplementation of EAAs as well as at discharge from the in-patient rehabilitation, at 12 weeks and 1 year afterwards. DISCUSSION: This is the first randomized double-blinded placebo-controlled clinical study aiming to assess the effect of the EAAs supplementation on muscle strength, muscle function and physical performance in stroke patients during early post-stroke rehabilitation. Supplementation of EAAs could prevent muscle mass wasting and improve functional independence after stroke. TRIAL REGISTRATION: The study is registered at the German registry for clinical trials as well as at World Health Organization (WHO; number DRKS00005577). BioMed Central 2016-01-22 /pmc/articles/PMC4722757/ /pubmed/26793971 http://dx.doi.org/10.1186/s12883-016-0531-5 Text en © Scherbakov et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Study Protocol
Scherbakov, Nadja
Ebner, Nicole
Sandek, Anja
Meisel, Andreas
Haeusler, Karl Georg
von Haehling, Stephan
Anker, Stefan D.
Dirnagl, Ulrich
Joebges, Michael
Doehner, Wolfram
Influence of essential amino acids on muscle mass and muscle strength in patients with cerebral stroke during early rehabilitation: protocol and rationale of a randomized clinical trial (AMINO-Stroke Study)
title Influence of essential amino acids on muscle mass and muscle strength in patients with cerebral stroke during early rehabilitation: protocol and rationale of a randomized clinical trial (AMINO-Stroke Study)
title_full Influence of essential amino acids on muscle mass and muscle strength in patients with cerebral stroke during early rehabilitation: protocol and rationale of a randomized clinical trial (AMINO-Stroke Study)
title_fullStr Influence of essential amino acids on muscle mass and muscle strength in patients with cerebral stroke during early rehabilitation: protocol and rationale of a randomized clinical trial (AMINO-Stroke Study)
title_full_unstemmed Influence of essential amino acids on muscle mass and muscle strength in patients with cerebral stroke during early rehabilitation: protocol and rationale of a randomized clinical trial (AMINO-Stroke Study)
title_short Influence of essential amino acids on muscle mass and muscle strength in patients with cerebral stroke during early rehabilitation: protocol and rationale of a randomized clinical trial (AMINO-Stroke Study)
title_sort influence of essential amino acids on muscle mass and muscle strength in patients with cerebral stroke during early rehabilitation: protocol and rationale of a randomized clinical trial (amino-stroke study)
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722757/
https://www.ncbi.nlm.nih.gov/pubmed/26793971
http://dx.doi.org/10.1186/s12883-016-0531-5
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